Table 3 Ten most significant SNPs associated with Framingham Risk Score using GWAS
SNP Rank | SNP ID | Region | Gene | Beta | P-value |
|---|---|---|---|---|---|
1 | rs17584191 | 5q23.2 | Intergenic; flanking LMNB1 | 0.09579 | 1.866e-05 |
2 | rs17051776 | 13q13 | NBEA | -0.28380 | 2.987e-05 |
3 | rs483487 | 3q26.31 | NLGN1 | 0.11820 | 3.239e-05 |
4 | rs215935 | 6q14-q15 | Intergenic; flanking TBX18 | -0.08192 | 4.258e-05 |
5 | rs1862523 | 5p14-p13 | Intergenic; flanking NPR3 | -0.08753 | 4.610e-05 |
6 | rs2111202 | 7q3 | NRCAM | 0.09009 | 5.237e-05 |
7 | rs12611756 | 2p12-p11.1 | CTNNA2 | 0.08251 | 5.875e-05 |
8 | rs1491609 | 3p13 | Intergenic; flanking FOXP1 | -0.08143 | 5.952e-05 |
9 | rs1346949 | 18q21.33 | Intergenic; flanking PIGN | -0.08592 | 6.730e-05 |
10 | rs17205291 | 1q42 | Intergenic; flanking KIAA1804 | 0.10680 | 6.860e-05 |