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Table 2 Regression coefficients used in models generating Framingham risk scores for 10-year risk of general cardiovascular disease

From: Recent methods for polygenic analysis of genome-wide data implicate an important effect of common variants on cardiovascular disease risk

Men*    Women*  
Variable Beta p-value Beta p-value
Log of Age 3.06117 p < .0001 2.32888 p < .0001
Log of Total Cholesterol 1.1237 p < .0001 1.20904 p < .0001
Log of HDL Cholesterol -0.93263 p < .0001 -0.70833 p < .0001
Log of SBP if not treated 1.933303 p < .0001 2.76157 p < .0001
Log of SBP if treated 1.99881 p < .0001 2.82263 p < .0001
Smoking 0.65451 p < .0001 0.52873 p < .0001
Diabetes 0.57367 p < .0001 0.69154 p < .0001
  1. The 10-year risk for women can be calculated as 1-0.95012exp(ΣβX - 26.1931) where Beta is the regression coefficient and × is the level for each risk factor; the risk for men is given as 1-0.88936exp(ΣβX - 23.9802) [20]