The human epidermal growth factor receptor (EGFR) gene in European patients with advanced colorectal cancer harbors infrequent mutations in its tyrosine kinase domain

Table 2 Mutations found in EGFR exons 18 to 21

Exon	Frequency	Mutation type	Heredity	K-ras status
		TTG to TCG (L707S) n2120 Ti	s	wt
		ACT to GCT (T710A) n2128 Ti	s	wt
18	5/188 (2.6%)	GAA to GTT (E711V) n2132/2133 Tv	s	wt
		TTC to TCC (F712S) n2135 Ti	s	wt
		ACG to ACA (T725T) n2175 Ti	g	wt
19	1/221 (0.5%)	*GTC to GTT (V742V) n2226 Ti*	g	wt
		TTC to TCC (F795S) n2384 Ti	s	wt
20	2/227 (0.8%)	GGC to AGC (G796S) n2386 Ti	g	Wt
		CGC to CGT (R836R) n2508 Ti	g	M (13)
		CGC to CGT (R836R) n2508 Ti	g	wt
		CGC to CGT (R836R) n2508 Ti	g	wt
		CGC to CGT (R836R) n2508 Ti	g	wt
21	9/236 (3.8%)	CGC to CGT (R836R) n2508 Ti	g	wt
		CGC to CGT (R836R) n2508 Ti	g	wt
		CGC to CGT (R836R) n2508 Ti	s	M (12)
		CGC to CGT (R836R) n2508 Ti	nd	wt
		*ACA to AGA (T847R) n2540 Tv*	g	Wt

Frequency as well as mutation type and heredity are shown. Bold characters underline mutations not described elsewhere and italic characters indicate silent point mutations. Nucleotides positions are marked with an n followed by the position number. Transversion or transition mutation types are marked by Tv or Ti respectively. Germline and somatic mutations are designated by g and s respectively and correspond to mutations found (germline, g) or not found (somatic, s, tumor specific) in peripheral blood-DNA of the same patients. KRAS mutations located within the codon 12 (M 12) or 13 (M13) are highlighted.

ISSN: 1471-2350