IL13genetic polymorphisms, smoking, and eczema in women: a case-control study in Japan

BMC Medical Genetics

Table 4 Interaction between IL13 rs1800925 polymorphism and smoking

	Smoking status
	No		Yes
SNP	No. of cases/controls	Adjusted OR (95% CI)*	No. of cases/controls	Adjusted OR (95% CI)*
CC + CT	119/727	1.00	59/328	1.06 (0.75-1.50)
TT	6/19	1.96 (0.76-5.03)	4/8	2.85 (0.83-9.73)
P for multiplicative interaction = 0.69
Measures of additive interaction^†
Relative excess risk due to interaction (RERI) = 0.83 (95% CI: -3.08-4.74)
Attributable proportion due to interaction (AP) = 0.29 (95% CI: -0.78-1.37)
Synergy index (S) = 1.82 (95% CI: 0.13-24.85)

* Adjusted for age, region of residence, number of children, and education.
^† Statistically significant with the 95% CI of RERI > 0, the 95% CI of AP > 0, or the 95% CI of S > 1, indicating additive interaction.

ISSN: 1471-2350