Table 2 Allelic and genotypic frequencies of ABCB1 and CYP2C19 gene polymorphisms according to ethnic groups
Nucleotide Change and Genotype n (100%) | Amerindian 183 | Caucasian descent 615 | Mulatto 315 | African descent 99 | pvalue |
|---|---|---|---|---|---|
ABCB1c.C3435T | |||||
CC | 45 (24.6%) | 206 (33.5%) | 131 (41.6%) | 47 (47.5%) | |
CT | 88 (48.1%) | 287 (46.7%) | 142 (45.1%) | 39 (39.4%) | <0.001 |
TT | 50 (27.3%) | 122 (19.8%) | 42 (13.3%) | 13 (13.1%) | |
T allele | 51.4% | 43.2% | 35.9% | 32.8% | <0.001 |
CYP2C19*2 , c.G681A | |||||
GG | 151 (83.1%) | 439 (71.4%) | 222 (70.5%) | 65 (65.7%) | |
GA | 24 (13.1%) | 144 (23.4%) | 82 (26.0%) | 28 (28.3%) | 0.013 |
AA | 7 (3.8%) | 32 (5.2%) | 11 (3.5%) | 6 (6.0%) | |
A allele | 10.4% | 16.9% | 16.5% | 20.2% | 0.007 |
CYP2C19*17, c.C806T | |||||
CC | 134 (73.2%) | 425 (69.1%) | 201 (63.8%) | 55 (55.6%) | |
CT | 40 (21.9%) | 158 (25.7%) | 94 (29.8%) | 36 (36.4%) | 0.065 |
TT | 9 (4.9%) | 32 (5.2%) | 20 (6.4%) | 8 (8.0%) | |
T allele | 15.8% | 18.0% | 21.3% | 26.3% | 0.048 |