Skip to main content

Table 1 Characteristics of studies included in the meta-analysis

From: Association of HLA-B*5801 allele and allopurinol-induced stevens johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis

Author Year Study Design SJS/TEN Casesa
Controls Data Collection Specific Requirement for Case Allopurinol-Exposureb Matching Criteria NOS
SJS/TEN Cases Controls    
Hung SI [10] 2005 Case-control 21 135 93c R R Yes Drug, hospital 7
Kaniwa N [11] 2008 Case-population controld 10 - 493e R - NR - 3
Lonjou C [12] 2008 Case-population controld 31 - 1822f R (N = 70), P (N = 80) - Yes - 3
Tassaneeyakul W [13] 2009 Case-controlg 27 54 - R R Yes Drug, hospital 7
Kang HR [14] 2011 Case-control 5 57 485h R R Yes Drug, hospital 4
Jung JW [15] 2011 Retrospective cohort 2 432 485h R R Yes Drug, hospital 6
  1. Abbreviation: R = retrospective, P = prospective, NOS = Newcastle-Ottawa Scale, NR = not report
  2. a Only patients that received drugs of interest (Allopurinol) were included.
  3. b Including: maximum time to develop adverse drug reaction (ADR) from drug initiation [10, 12, 13], improvement of symptom upon drug discontinuation [10, 13], and exclusion of patients without symptoms upon re-exposure [10].
  4. c Healthy subjects randomly selected from a biobank under nationwide population study, in which 3312 Han Chinese descendants were recruited based on the geographic distribution across Taiwan. There was no self-report of adverse drug events by any of the population control.
  5. d Using population based as control group.
  6. e Data of healthy Japanese reported by Tanaka H, et al. [20].
  7. f Using allele frequencies from European populations available on dbMHC:
  8. g Author described the study as cross-sectional case-control study.
  9. h Using allele frequency from the general population of Korea.