Genome-Wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population

Table 3 MAPT-NSF and MAPT-WNT3 interaction in the Ashkenazi Jewish Dataset: Multivariate logistic regression*

	MAPT	NSF	WNT3	Ashkenazi Jewish			NINDS			CIDR/Pankratz et al 2009
Single point	rs1981997	rs183211	rs415430	P-value	OR	95% CI	P-value	OR	95% CI	P-value	OR	95% CI
	A			0.0009118	0.58	0.42-0.90	0.07504	0.86	0.73-1.01	0.0001569	0.72	0.61-0.86
		T		6.68 × 10^-5	0.54	0.40-0.73	0.1015	0.87	0.74-1.02	0.001375	0.77	0.65-0.90
			C	8.59 × 10^-5	0.54	0.30-0.74	0.002397	0.77	0.65-0.91		N/A
2-mer	rs1981997	rs183211	rs415430	P-value	Freq. Cases	Freq. Controls	P-value	Freq. Cases	Freq. Controls	P-value	Freq. Cases	Freq. Controls
	G	C		0.00034	0.7743	0.6657	0.2634	0.7654	0.7491	0.0003	0.791	0.7386
	A	C		0.2118	0.0187	0.0084	0.1986	0.0217	0.0157	0.1059	0.0128	0.0198
	G	T		0.3211	0.0466	0.0618	0.2344	0.0444	0.0364	0.9238	0.0326	0.0332
	A	T		0.00016	0.1604	0.264	0.0214	0.1685	0.1989	0.0007	0.1636	0.2084
		T	C	0.00023	0.1559	0.2558	0.0145	0.1647	0.1967
		C	C	0.2912	0.0456	0.0617	0.0191	0.0081	0.0169
		T	T	0.2408	0.0512	0.0701	0.2133	0.0482	0.0395
		C	T	1.91 × 10 ^-5	0.7473	0.6125	0.0269	0.7790	0.7469		N/A
3-mer	A	T	C	0.00018	0.156	0.2585	0.0133	0.1626	0.1951
	G	C	C	0.3544	0.0445	0.0584	0.0134	0.0081	0.0175
	G	T	T	0.2446	0.0450	0.0628	0.2758	0.0422	0.0350
	A	C	T	0.1172	0.0194	0.0066	0.2187	0.0222	0.0163
	G	C	T	0.00014	0.7351	0.6137	0.0518	0.7649	0.7361		N/A

*Adjusted for age and sex. Age refers to age at onset for affected individuals, and age at examination for unaffected individuals. OR: odds ratios, 95% CI: 95% confidence interval; P-values for allelic/haplotype association; Single point shows the protective allele of each SNP; N/A, SNP rs415430 is not available in PD/CIDR data.