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Table 3 MAPT-NSF and MAPT-WNT3 interaction in the Ashkenazi Jewish Dataset: Multivariate logistic regression*

From: Genome-Wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population

  MAPT NSF WNT3 Ashkenazi Jewish NINDS CIDR/Pankratz et al 2009
Single point rs1981997 rs183211 rs415430 P-value OR 95% CI P-value OR 95% CI P-value OR 95% CI
  A    0.0009118 0.58 0.42-0.90 0.07504 0.86 0.73-1.01 0.0001569 0.72 0.61-0.86
   T   6.68 × 10-5 0.54 0.40-0.73 0.1015 0.87 0.74-1.02 0.001375 0.77 0.65-0.90
    C 8.59 × 10-5 0.54 0.30-0.74 0.002397 0.77 0.65-0.91   N/A  
2-mer rs1981997 rs183211 rs415430 P-value Freq. Cases Freq. Controls P-value Freq. Cases Freq. Controls P-value Freq. Cases Freq. Controls
  G C   0.00034 0.7743 0.6657 0.2634 0.7654 0.7491 0.0003 0.791 0.7386
  A C   0.2118 0.0187 0.0084 0.1986 0.0217 0.0157 0.1059 0.0128 0.0198
  G T   0.3211 0.0466 0.0618 0.2344 0.0444 0.0364 0.9238 0.0326 0.0332
  A T   0.00016 0.1604 0.264 0.0214 0.1685 0.1989 0.0007 0.1636 0.2084
   T C 0.00023 0.1559 0.2558 0.0145 0.1647 0.1967    
   C C 0.2912 0.0456 0.0617 0.0191 0.0081 0.0169    
   T T 0.2408 0.0512 0.0701 0.2133 0.0482 0.0395    
   C T 1.91 × 10 -5 0.7473 0.6125 0.0269 0.7790 0.7469   N/A  
3-mer A T C 0.00018 0.156 0.2585 0.0133 0.1626 0.1951    
  G C C 0.3544 0.0445 0.0584 0.0134 0.0081 0.0175    
  G T T 0.2446 0.0450 0.0628 0.2758 0.0422 0.0350    
  A C T 0.1172 0.0194 0.0066 0.2187 0.0222 0.0163    
  G C T 0.00014 0.7351 0.6137 0.0518 0.7649 0.7361   N/A  
  1. *Adjusted for age and sex. Age refers to age at onset for affected individuals, and age at examination for unaffected individuals. OR: odds ratios, 95% CI: 95% confidence interval; P-values for allelic/haplotype association; Single point shows the protective allele of each SNP; N/A, SNP rs415430 is not available in PD/CIDR data.
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BMC Medical Genetics

ISSN: 1471-2350

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