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Table 3 MAPT-NSF and MAPT-WNT3 interaction in the Ashkenazi Jewish Dataset: Multivariate logistic regression*

From: Genome-Wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population

 

MAPT

NSF

WNT3

Ashkenazi Jewish

NINDS

CIDR/Pankratz et al 2009

Single point

rs1981997

rs183211

rs415430

P-value

OR

95% CI

P-value

OR

95% CI

P-value

OR

95% CI

 

A

  

0.0009118

0.58

0.42-0.90

0.07504

0.86

0.73-1.01

0.0001569

0.72

0.61-0.86

  

T

 

6.68 × 10-5

0.54

0.40-0.73

0.1015

0.87

0.74-1.02

0.001375

0.77

0.65-0.90

   

C

8.59 × 10-5

0.54

0.30-0.74

0.002397

0.77

0.65-0.91

 

N/A

 

2-mer

rs1981997

rs183211

rs415430

P-value

Freq. Cases

Freq. Controls

P-value

Freq. Cases

Freq. Controls

P-value

Freq. Cases

Freq. Controls

 

G

C

 

0.00034

0.7743

0.6657

0.2634

0.7654

0.7491

0.0003

0.791

0.7386

 

A

C

 

0.2118

0.0187

0.0084

0.1986

0.0217

0.0157

0.1059

0.0128

0.0198

 

G

T

 

0.3211

0.0466

0.0618

0.2344

0.0444

0.0364

0.9238

0.0326

0.0332

 

A

T

 

0.00016

0.1604

0.264

0.0214

0.1685

0.1989

0.0007

0.1636

0.2084

  

T

C

0.00023

0.1559

0.2558

0.0145

0.1647

0.1967

   
  

C

C

0.2912

0.0456

0.0617

0.0191

0.0081

0.0169

   
  

T

T

0.2408

0.0512

0.0701

0.2133

0.0482

0.0395

   
  

C

T

1.91 × 10 -5

0.7473

0.6125

0.0269

0.7790

0.7469

 

N/A

 

3-mer

A

T

C

0.00018

0.156

0.2585

0.0133

0.1626

0.1951

   
 

G

C

C

0.3544

0.0445

0.0584

0.0134

0.0081

0.0175

   
 

G

T

T

0.2446

0.0450

0.0628

0.2758

0.0422

0.0350

   
 

A

C

T

0.1172

0.0194

0.0066

0.2187

0.0222

0.0163

   
 

G

C

T

0.00014

0.7351

0.6137

0.0518

0.7649

0.7361

 

N/A

 
  1. *Adjusted for age and sex. Age refers to age at onset for affected individuals, and age at examination for unaffected individuals. OR: odds ratios, 95% CI: 95% confidence interval; P-values for allelic/haplotype association; Single point shows the protective allele of each SNP; N/A, SNP rs415430 is not available in PD/CIDR data.