Table 3 Six SNPs Showing Association with FVIII Activity Across the Three GWAS Datasets With Combined Significance P-value < 10-5
From: Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels
Gene | SNP | Alleles* | MAF+ | β (SE) | p | I2 | phet | Random Effect | Fixed Effect | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
β (SE) | p | β (SE) | p | |||||||||
FVL | 0.41 | -0.12 (0.09) | 0.156 | |||||||||
LBH | rs6708166 | G/A | Martha08 | 0.40 | -0.23 (0.06) | 8.98e-05 | 0 | 0.478 | -0.17 (0.04) | 1.32 10-6 | -0.17 (0.04) | 1.30 10-6 |
Martha10 | 0.42 | -0.15 (0.05) | 0.007 | |||||||||
FVL | 0.42 | -0.20 (0.08) | 0.014 | |||||||||
FAM46A | rs1321761 | T/C | Martha08 | 0.45 | -0.10 (0.06) | 0.074 | 0 | 0.451 | -0.15 (0.04) | 9.67 10-6 | -0.15 (0.04) | 9.54 10-6 |
Martha10 | 0.47 | -0.19 (0.05) | 5.93e-04 | |||||||||
FVL | 0.17 | 0.28 (0.11) | 0.012 | |||||||||
VAV2 | rs12344583 | A/G | Martha08 | 0.20 | 0.19 (0.07) | 0.006 | 0 | 0.716 | 0.20 (0.04) | 8.03 10-6 | 0.20 (0.04) | 7.92 10-6 |
Martha10 | 0.18 | 0.17 (0.07) | 0.012 | |||||||||
FVL | 0.16 | 0.52 (0.12) | 1.36e-05 | |||||||||
STAB2 | rs7306642 | C/A | Martha08 | 0.07 | 0.22 (0.11) | 0.057 | 0.59 | 0.086 | 0.31 (0.10) | 0.002 | 0.30 (0.06) | 2.95 10-6 |
Martha10 | 0.07 | 0.20 (0.1) | 0.052 | |||||||||
FVL | 0.53 | 0.09 (0.08) | 0.293 | |||||||||
rs1354492 | G/A | Martha08 | 0.49 | 0.23 (0.05) | 1.20e-05 | 0.39 | 0.192 | 0.16 (0.04) | 5.47 10-6 | 0.16 (0.03) | 2.41 10-6 | |
ACCN1 | Martha10 | 0.47 | 0.12 (0.05) | 0.027 | ||||||||
FVL | 0.22 | -0.29 (0.1) | 0.004 | |||||||||
rs12941510 | G/A | Martha08 | 0.31 | -0.17 (0.06) | 0.002 | 0.12 | 0.321 | -0.17 (0.04) | 2.18 10-5 | -0.17 (0.04) | 5.67 10-6 | |
Martha10 | 0.33 | -0.12 (0.06) | 0.029 | |||||||||