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Table 2 Top associated SNPs (p < 00.001) in the overall sample on chromosome 12p11

From: A follow-up study for left ventricular mass on chromosome 12p11 identifies potential candidate genes

      Overall Data Set (N = 897) Dominican Subset (N = 368)
SNP MB Gene Function Minor Allele MAF Beta SE P* MAF Beta SE P†
rs10743465 23.315 SOX5 flanking A 0.202 -0.066 0.015 1.27E-05 0.23 -0.043 0.022 5.11E-02
rs4321001 23.323 SOX5 flanking A 0.195 -0.064 0.015 1.69E-05 0.22 -0.036 0.021 9.76E-02
rs16919217 32.110 BICD1 flanking C 0.079 -0.085 0.020 2.31E-05 0.11 -0.082 0.027 2.68E-03
rs6582621 44.878 SLC38A1 intron A 0.268 -0.054 0.013 3.91E-05 0.29 -0.062 0.020 2.17E-03
rs16919218 32.110 BICD1 flanking T 0.082 -0.081 0.020 4.96E-05 0.11 -0.082 0.027 2.99E-03
rs7958592 23.399 SOX5 flanking C 0.340 -0.048 0.012 6.33E-05 0.38 -0.047 0.018 7.80E-03
rs11183394 44.882 SLC38A1 intron A 0.239 -0.054 0.013 6.50E-05 0.25 -0.060 0.021 4.30E-03
rs10047623 23.368 SOX5 flanking G 0.092 -0.078 0.020 8.28E-05 0.12 -0.066 0.027 1.70E-02
rs4129991 23.340 SOX5 flanking G 0.202 -0.059 0.015 8.28E-05 0.23 -0.038 0.021 7.54E-02
rs7307902 46.209 intergenic   G 0.213 0.050 0.014 2.98E-04 0.19 0.022 0.022 3.14E-01
rs1967110 48.681 RACGAP1 intron G 0.086 -0.075 0.021 2.99E-04 0.09 -0.063 0.031 3.86E-02
rs7133522 44.888 SLC38A1 intron T 0.292 -0.046 0.013 3.48E-04 0.31 -0.055 0.019 4.53E-03
rs12310555 29.278 FAR2 intron A 0.189 -0.053 0.015 3.97E-04 0.21 -0.083 0.023 2.88E-04
rs7955257 23.376 SOX5 flanking T 0.260 -0.044 0.013 4.64E-04 0.28 -0.038 0.019 4.78E-02
rs17128396 39.198 intergenic   A 0.063 -0.082 0.024 5.80E-04 0.07 -0.055 0.034 1.03E-01
rs7956629 44.877 SLC38A1 intron A 0.120 -0.061 0.018 7.18E-04 0.14 -0.065 0.026 1.27E-02
rs7310702 44.535 ARID2 intron G 0.168 -0.055 0.016 7.78E-04 0.19 -0.044 0.023 5.90E-02
rs12227330 49.969 BIN2 intron A 0.121 -0.063 0.019 7.95E-04 0.12 -0.062 0.028 2.98E-02
rs10875764 46.869 C12orf68 flanking C 0.482 0.039 0.012 8.34E-04 0.46 0.035 0.019 5.94E-02
rs309045 28.841 intergenic   A 0.413 0.039 0.012 9.07E-04 0.36 0.017 0.018 3.39E-01
  1. *adjused for PCA1, PCA2, age, sex, hypertension, diabetes, BMI, WC, and years between LVM and risk factor measurements
  2. † adjusted for PCA1, age, sex, hypertension, diabetes, BMI, WC, and years between LVM and risk factor measurements.