IL23Rstratum defined using the p.Arg381Gln polymorphism 1) | CT60 (rs3087243), A carriage rate (genotypes A/G, A/A) | JO31 (rs11571302), T carriage rate (genotypes G/T, T/T) | JO27-1 (rs11571297), G carriage rate (genotypes A/G, G/G) | Haplotype "ATG" 4 |
---|---|---|---|---|
IL23R"-" | Â | Â | Â | Â |
   cases, n = 21 | 10 (48%) | 10 (48%) | 10 (48%) |  |
   controls, n = 50 | 42 (84%) | 40 (80%) | 40 (80%) |  |
   OR (95%CI) 2) | 0.23 (0.07-0.71) | 0.26 (0.08-0.85) | 0.24 (0.07-0.79) | 0.30 (0.11 - 0.81) |
IL23R "wt/wt" | Â | Â | Â | Â |
   cases, n = 312 | 214 (69%) | 224 (72%) | 227 (73%) |  |
   controls, n = 432 | 276 (64%) | 292 (68%) | 296 (69%) |  |
   OR (95%CI) 2) | 1.26 (0.91-1.74) | 1.22 (0.87-1.71) | 1.21 (0.86-1.69) | 1.20 (0.96 - 1.51) |
Heterogeneity between IL23R -defined strata 3) | p = 0.0061 | p = 0.011 | p = 0.011 | p = 0.030 |