A gene-wide investigation on polymorphisms in the taste receptor 2R14 (TAS2R14) and susceptibility to colorectal cancer

Table 2 Associations of TAS2R14 tagging polymorphisms with colorectal cancer risk

	Position on Chromosome 12	Cases^a	Controls^a	OR (95%)^b	P value	P trend
rs3916060	10,984,340
T/T		603	537	1		1.00
T/C		52	50	0.93 (0.62-1.39)	0.71
C/C		2	0	N.A.	N.A.
T/C+C/C		54	50	0.96 (0.64-1.44)	0.85
rs3741843	10,982,699
A/A		509	450	1		0.32
A/G		143	109	1.11 (0.43-2.82)	0.83
G/G		10	8	1.16 (0.88-1.53)	0.30
A/G+GG		153	117	1.16(0.88-1.52)	0.30
rs11610105	10,980,242
G/G		304	283	1		0.75
A/G		275	239	0.84(0.56-1.25)	0.39
A/A		55	61	1.07(0.84-1.36)	0.57
A/G+GG		330	300	1.02(0.82-1.28)	0.84

^a Numbers may not add up to 100% of subjects due to genotyping failure. All samples that did not give a reliable result in the first round of genotyping were resubmitted to up to two additional rounds of genotyping. Data points that were still not filled after this procedure were left blank.
^b OR: odds ratio; CI: confidence interval. Adjusted for age and gender.

ISSN: 1471-2350