Association of obesity risk SNPs in PCSK1with insulin sensitivity and proinsulin conversion

Heni, Martin; Haupt, Axel; Schäfer, Silke A; Ketterer, Caroline; Thamer, Claus; Machicao, Fausto; Stefan, Norbert; Staiger, Harald; Häring, Hans-Ulrich; Fritsche, Andreas

doi:10.1186/1471-2350-11-86

BMC Medical Genetics

Table 1 Associations of PCSK1 SNP rs6232 with anthropometrics, metabolic parameters, and proinsulin conversion

From: Association of obesity risk SNPs in PCSK1with insulin sensitivity and proinsulin conversion

SNP	rs6232 (encoding N221D)
Genotype	AA	AG	GG	β_adj ± SEM	p_dom	p_add
N (f/m)	1305(875/430)	173(106/67)	5(3/2)	-	-	-
Age (years)	39 ± 0.4	40 ± 1	37.6 ± 4	-	-	-
BMI (kg/m²)	28.5 ± 0.2	28.3 ± 0.6	29.1 ± 6.1	-0.003 ± 0.001	0.8	1.0
Waist circumference (cm)	93.4 ± 0.5	93.1 ± 1.2	82.3 ± 3.5	-0.005 ± 0.007	0.6	0.9
Total body fat (%)	31.0 ± 0.3	29.6 ± 0.8	30.4 ± 7	-0.017 ± 0.013	0.07	0.4
Fasting glucose (mmol/l)	5.1 ± 0.1	5.1 ± 0.1	5.4 ± 0.4	-0.004 ± 0.004	0.3	0.2
Glucose_120-min (mmol/l)	6.3 ± 0.1	5.9 ± 0.1	6.8 ± 1.2	-0.035 ± 0.010	0.0003	0.0006
Fasting insulin (pmol/l)	63 ± 1	56 ± 3	59.8 ± 33	-0.041 ± 0.019	0.0297	0.07
Insulin sensitivity, OGTT (AU)	16.3 ± 0.3	18.5 ± 0.9	25.8 ± 7	0.068 ± 0.020	0.0010	0.0030
Insulin sensitivity, clamp-derived (AU) (N = 512)	0.083 ± 0.003 (N = 443)	0.098 ± 0.007 (N = 68)	0.135 (N = 1)	0.085 ± 0.030	0.0047	-
HOMA_IR (mU × mmol × l^-2)	2.4 ± 0.1	2.1 ± 0.1	2.7 ± 1.8	-0.045 ± 0.020	0.0232	0.07
AUC_Ins30/AUC_Glc30 (×10^-9)	41.2 ± 0.9	36.8 ± 2.0	28.1 ± 8.3	-0.001 ± 0.017	1.0	0.6
First-phase insulin (pmol/l)	1267 ± 24	1160 ± 53	1046 ± 273	0.015 ± 0.017	0.4	0.7
AUC_C-Pep/AUC_Glc (×10^-9)	319 ± 3	319 ± 8	272 ± 29	0.020 ± 0.011	0.08	0.2
Proinsulin_0-min (pmol/l)	5.8 ± 0.2	5.6 ± 0.4	12.8 ± 8.4	0.053 ± 0.038	0.2	0.2
Proinsulin_30-min (pmol/l)	11.8 ± 0.4	11.9 ± 0.7	18.6 ± 3.7	0.073 ± 0.035	0.0377	0.0190
AUC_Proins (pmol/l)	36.2 ± 1.0	37.2 ± 2.4	52.1 ± 12.7	0.074 ± 0.030	0.0141	0.0089
Fasting proinsulin/fasting insulin	0.128 ± 0.002	0.135 ± 0.003	0.179 ± 0.008	0.040 ± 0.039	0.3	0.3
Proinsulin_30-min/insulin_30-min	0.036 ± 0.004	0.035 ± 0.002	0.064 ± 0.004	0.079 ± 0.037	0.0346	0.0158
AUC_Proins/AUC_Ins	0.050 ± 0.016	0.058 ± 0.034	0.111 ± 0.017	0.079 ± 0.030	0.0094	0.0026

Data represent unadjusted means ± SEM. For statistical analysis, data were ln-transformed and adjusted for gender and age. Glucose concentrations and insulin sensitivity indices were additionally adjusted for BMI. Proinsulin values as well as insulin secretion parameters were additionally adjusted for BMI and insulin sensitivity (OGTT). AUC - area under the curve; β_adj - effect sizes from the adjusted dominant model; BMI - body mass index; HOMA_IR - homeostasis model assessment-estimated insulin resistance; OGTT - oral glucose tolerance test; p_add - p-values from the additive inheritance model; p_dom - p-values from the dominant inheritance model; SNP - single nucleotide polymorphism. p-values withstanding Bonferroni correction for multiple comparisons are given in bold.

Back to article page

ISSN: 1471-2350

Contact us

General enquiries: ORSupport@springernature.com