Table 2 Four SNPs and their relationships with nasal polyposis under three genetic models
From: Matrix metalloproteinase-9gene polymorphisms in nasal polyposis
SNP | disease status | Genotype (n)(%) | p | ||||
|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | Â | Dominant | Additive | Recessive |
rs3918242 | case | TT(6)(3%) | CT(44)(21.7%) | CC(137)(67.5%) | 0.023* | 0.012* | 0.097 |
(promoter) | control | TT(4)(0.5%) | CT(125)(17.1%) | CC(560)(76.7%) | Â | Â | Â |
rs2664538 | case | AA(16)(7.9%) | AG(57)(28.1%) | GG(119)(58.6%) | 0.640 | 0.752 | 0.073 |
(in exon 6) | control | AA(37)(4.7%) | AG(246)(33.7%) | GG(428)(58.6%) | Â | Â | Â |
rs3787268 | case | AA(28)(13.8%) | AG(90)(44.3%) | GG(74)(36.5%) | 0.503 | 0.345 | 0.361 |
(intron 8) | control | AA(135)(18.5%) | AG(335)(45.9%) | GG(246)(33.7%) | Â | Â | Â |
rs2274756 | case | AA(6)(3%) | AG(49)(24.1%) | GG(137)(67.5%) | 0.034* | 0.020* | 0.134 |
(exon 12) | control | AA(5)(0.7%) | AG(147)(20.1%) | GG(572)(78.4%) | Â | Â | Â |
Recurrent cases(n = 64) | |||||||
rs3918242 | case | TT(2)(3%) | CT(12)(18.8%) | CC(43)(67.2%) | 0.382 | 0.243 | 0.175 |
| Â | control | TT(4)(0.5%) | CT(125)(17.1%) | CC(560)(76.7%) | Â | Â | Â |
rs2664538 | case | AA(7)(10.9%) | AG(18)(28.1%) | GG(36)(56.3%) | 0.841 | 0.314 | 0.033* |
| Â | control | AA(37)(4.7%) | AG(246)(33.7%) | GG(428)(58.6%) | Â | Â | Â |
rs3787268 | case | AA(8)(12.5%) | AG(27)(42.2%) | GG(26)(40.6) | 0.439 | 0.290 | 0.318 |
| Â | control | AA(135)(18.5%) | AG(335)(45.9%) | GG(246)(33.7%) | Â | Â | Â |
rs2274756 | case | AA(2)(3%) | AG(15)(23.4%) | GG(44)(68.8%) | 0.383 | 0.273 | 0.264 |
| Â | control | AA(5)(0.7%) | AG(147)(20.1%) | GG(572)(78.4%) | Â | Â | Â |
Non-recurrent cases(n = 139) | Â | Â | Â | ||||
rs3918242 | case | TT(4)(2.9%) | CT(32)(23%) | CC(94)(67.6%) | 0.021* | 0.014* | 0.159 |
| Â | control | TT(4)(0.5%) | CT(125)(17.1%) | CC(560)(76.7%) | Â | Â | Â |
rs2664538 | case | AA(9)(6.5%) | AG(39)(28.1%) | GG(83)(59.7%) | 0.356 | 0.592 | 0.561 |
| Â | control | AA(37)(4.7%) | AG(246)(33.7%) | GG(428)(58.6%) | Â | Â | Â |
rs3787268 | case | AA(20)(14.4%) | AG(63)(45.3%) | GG(48)(34.5%) | 0.990 | 0.824 | 0.690 |
| Â | control | AA(135)(18.5%) | AG(335)(45.9%) | GG(246)(33.7%) | Â | Â | Â |
rs2274756 | case | AA(4)(2.9%) | AG(34)(24.5%) | GG(93)(66.9%) | 0.037* | 0.026* | 0.203 |
| Â | control | AA(5)(0.7%) | AG(147)(20.1%) | GG(572)(78.4%) | Â | Â | Â |