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Table 3 Epistasis effects for TC and HDL-C with the significance of suggestive linkage.

From: Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham Heart Study data

           P value   
SNP1 Chr1 Pos1 Gene1 MAF1 SNP2 Chr2 Pos2 Gene2 MAF2 Genotype Epistasis Effect
TC
rs4437278 4 12488199 U6 a (174 kb) 0.15 rs705169 10 125285443 GRP26(140 kb) 0.49 4.49E-10 AA 5.93E-12 0.249 ± 0.036
rs4738150 8 72607907 U8 a (120 kb) 0.40 rs16918936 9 33009027 APTX, LOC646808 0.04 4.68E-13 AD 1.29E-12 -1.348 ± 0.188
HDL-C
rs10476539 5 91991628 AC026781.5 a (62 kb) 0.18 rs2392885 8 129003117 PVT1 a 0.28 2.63E-10 AA 2.99E-12 -0.269 ± 0.037
rs4706271 6 70390132 LMBRD1(intron14) 0.41 rs6581219 12 59213144 LRIG3(53 kb) 0.42 7.67E-11 DD 5.72E-13 -0.412 ± 0.056
rs7741758 6 70412380 LMBRD1(intron9) 0.41 rs6581219 12 59213144 LRIG3(53 kb) 0.42 5.73E-10 DD 4.60E-12 -0.388 ± 0.054
rs9346333 6 70426479 LMBRD1(intron8) 0.41 rs6581219 12 59213144 LRIG3(53 kb) 0.42 1.39E-10 DD 1.16E-12 -0.398 ± 0.054
rs9351772 6 70428200 LMBRD1(intron8) 0.41 rs6581219 12 59213144 LRIG3(53 kb) 0.42 5.38E-10 DD 4.25E-12 -0.390 ± 0.055
rs7762400 6 70445634 LMBRD1(intron7) 0.41 rs6581219 12 59213144 LRIG3(53 kb) 0.42 4.41E-10 DD 3.52E-12 -0.388 ± 0.054
rs9294851 6 70457629 LMBRD1(intron5) 0.41 rs6581219 12 59213144 LRIG3(53 kb) 0.42 2.83E-10 DD 2.22E-12 -0.392 ± 0.054
rs9354890 6 70504296 LMBRD1(intron1) 0.41 rs6581219 12 59213144 LRIG3(53 kb) 0.42 5.54E-10 DD 4.18E-12 -0.388 ± 0.054
rs9364063 6 70514750 LMBRD1(8 kb) 0.41 rs6581219 12 59213144 LRIG3(53 kb) 0.42 4.65E-10 DD 4.46E-12 -0.386 ± 0.054
rs2787520 6 106821428 ATG5(48 kb) 0.35 rs7236739 18 20800715 CABLES1(intron4) 0.31 2.98E-10 AA 2.48E-12 -0.211 ± 0.029
rs2842169 10 128330713 AL583860.7 a (85 kb) 0.10 rs4756344 11 36765284 C11orf74(84 kb) 0.26 3.56E-10 AA 3.73E-12 0.348 ± 0.049
rs17623128 16 77630108 AC092724.2 a (114 kb) 0.33 rs6506699 18 9775566 RAB31 0.49 4.65E-10 DD 2.78E-12 -0.449 ± 0.062
rs12596869 16 77630380 AC092724.2 a (114 kb) 0.33 rs6506699 18 9775566 RAB31 0.49 3.81E-10 DD 2.30E-12 -0.451 ± 0.062
  1. a This was an RNA gene.