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Table 2 Single-locus SNP effects for HDL-C with genome control (GC) adjusted P < 7.2 × 10-8.

From: Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham Heart Study data

       Effect Type & P value  
SNP Chr Position Gene Region Reported SNP effect MAF Genotype Additive Effect Size
rs17482753 8 19832646 8 kb downstream LPL a Triglyceride [7] 0.10 1.27E-08 3.50E-09 -0.191 ± 0.031
rs10503669 8 19847690 23 kb downstream LPL a HDL-C [4, 11] 0.09 3.75E-08 1.14E-08 -0.189 ± 0.031
rs17410962 8 19848080 23 kb downstream LPL a   0.12 2.75E-08 4.27E-09 0.173 ± 0.028
rs17489268 8 19852045 27 kb downstream LPL a   0.27 2.28E-10 5.97E-11 0.141 ± 0.02
rs17411031 8 19852310 28 kb downstream LPL a HDL-C [7] 0.27 3.06E-10 7.21E-11 -0.14 ± 0.02
rs17489282 8 19852518 28 kb downstream LPL a   0.25 2.33E-09 6.54E-10 0.14 ± 0.021
rs4922117 8 19852586 28 kb downstream LPL a   0.25 2.28E-09 7.73E-10 -0.124 ± 0.019
rs17411126 8 19855272 31 kb downstream LPL a   0.27 6.14E-10 1.23E-10 0.138 ± 0.02
rs765547 8 19866274 42 kb downstream LPL a   0.27 1.60E-10 3.07E-11 -0.142 ± 0.02
rs11986942 8 19867445 43 kb downstream LPL a   0.33 2.22E-07 5.53E-08 0.112 ± 0.02
rs1837842 8 19868290 44 kb downstream LPL a   0.27 2.14E-10 4.09E-11 0.142 ± 0.02
rs1919484 8 19869676 45 kb downstream LPL a   0.27 4.12E-10 7.21E-11 -0.143 ± 0.021
rs17259942 12 77072077 OSBPL8-ZDHHC17   0.12 8.61E-08 1.81E-08 0.168 ± 0.028
rs9989419 16 56985139 HERPUD1-CETP a HDL-C [4, 7] 0.40 4.57E-13 5.96E-14 -0.147 ± 0.019
rs1800775 16 56995236 0.5 kb upstream CETP a HDL-C [3, 12] 0.45 1.54E-29 1.64E-30 0.242 ± 0.02
rs7240405 18 47159090 LIPG a-ACAA2 b   0.16 8.01E-08 1.58E-08 -0.145 ± 0.024
rs4939883 18 47167214 LIPG a-ACAA2 b HDL-C [1, 2] 0.17 1.07E-07 1.85E-08 0.142 ± 0.024
rs1943981 18 47169815 LIPG a-ACAA2 b   0.17 1.49E-07 2.50E-08 0.142 ± 0.024
rs2156552 18 47181668 LIPG a-ACAA2 b HDL-C [3, 4] 0.16 5.87E-08 1.14E-08 -0.146 ± 0.024
rs6507945 18 47243912 LIPG a-ACAA2 b   0.43 4.34E-08 6.91E-09 0.113 ± 0.018
  1. a This gene was reported in [14].
  2. b This gene was reported in [3].