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Table 3 Allele and genotype frequencies of SNPs in ADPRT1, AKR1B1, RAGE, GFPT2, PAI and their association status with diabetic CRI, and the power of sample size to detect association at 5% significance level.

From: Association analysis of ADPRT1, AKR1B1, RAGE, GFPT2 and PAI-1 gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes

SNPs Allele frequency Genotype frequency Association Power (G %)
  DM CRI DM CRI Allele Genotype  
  (n = 225)
(n = 196)
  (n = 225) (n = 196) (df = 1) (df = 2)  
ADPRT1
T>C
T = 0.91
C = 0.09
T = 0.925
C = 0.075
TT = 0.87
TC = 0.12
CC = 0.01
TT = 0.83
TC = 0.16
CC = 0.01
χ2 = 0.21;
P = 0.64,
P* = 0.13
χ2 = 1.61;
P = 0.45;
P* = 0.11
12
ADPRT1
A>G
A = 0.91
G = 0.09
A = 0.92
G = 0.08
AA = 0.83
AG = 0.17
GG = 0.00
AA = 0.84
AG = 0.14
GG = 0.02
χ2 = 0.07;
P = 0.79;
P* = 0.13
χ2 = 3.3;
P = 0.19;
P* = 0.14
8
AKR1B1
G>C
G = 0.93
C = 0.07
G = 0.93
C = 0.07
GG = 0.86
GC = 0.14
CC = 0.00
GG = 0.89
GC = 0.11
CC = 0.00
χ2 = 0.88;
P = 0.35;
P* = 0.15
χ2 = 0.94;
P = 0.33
(df = 1);
P* = 0.14
0
RAGE
-429T>C
T = 0.87
C = 0.13
T = 0.88
C = 0.12
TT = 0.77
TC = 0.22
CC = 0.01
TT = 0.81
TC = 0.14
CC = 0.05
χ2 = 0.04;
P = 0.84;
P* = 0.11
χ 2 = 8.68;
P = 0.013;
P* = 0.015
OR = 9.03, 95% CI = (1.09<OR<74.26)
7
RAGE
63 bp ins/del
Ins = 0.96
Del = 0.04
Ins = 0.97
Del = 0.03
Ins/Ins = 0.95
Ins/Del = 0.05
Del/Del = 0.00
Ins/Ins = 0.91
Ins/Del = 0.09
Del/Del = 0.00
χ2 = 0.26;
P = 0.60;
P* = 0.15
P* = 0.06 12
GFPT2
C>T
C = 0.78
T = 0.22
C = 0.72
T = 0.28
CC = 0.50
CT = 0.45
TT = 0.05
CC = 0.60
CT = 0.37
TT = 0.03
χ 2 = 3.92;
P = 0.047;
P* = 0.03
OR = 1.38, 95% CI = (1.02<OR<1.98)
χ2 = 4.5;
P = 0.11;
P* = 0.04
51
PAI-1 4G/5G (del/ins) 4G = 0.52
5G = 0.48
4G = 0.49
5G = 0.51
4G4G = 0.23
4G5G = 0.52
5G5G = 0.25
4G4G = 0.29
4G5G = 0.46
5G5G = 0.25
χ2 = 0.84;
P = 0.36;
P* = 0.06
χ2 = 2.5;
P* = 0.29
14
  1. P:P value for Pearson's chi-square test
  2. P*: Fisher's exact P value.