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Table 2 Results of the single SNP association analysis of a 470 kb region on 2q11.2 in hand OA study sample.

From: Allelic variants of IL1R1gene associate with severe hand osteoarthritis

   Controls Hand OA
     p-values
Gene SNP MAF MAF χ2 Pseudomarker
I rs740044 0.178 0.155 0.507a 0.517
  rs4141134 0.269 0.250 0.635a 0.327
IL1R2 rs719250 0.182 0.177 0.867 0.382
  rs3218934 0.406 0.456 0.246 0.086
  rs3218984 0.394 0.424 0.472 0.185
II rs1008394 0.394 0.439 0.281 0.083
  rs2310173 0.304 0.351 0.226 0.370
IL1R1 rs1465325 0.195 0.119 0.022 a 0.005
  rs956730 0.260 0.204 0.140a 0.026
  rs3917225 0.396 0.309 0.043 0.078
  rs2287047 0.249 0.159 0.013 a 0.0009 b
  rs3771200 0.411 0.453 0.312 0.539
IL1RL2 rs2241132 0.158 0.141 0.644a 0.491
  rs870684 0.378 0.394 0.690 0.781
  rs1922290 0.377 0.420 0.304 0.495
  rs1922295 0.379 0.400 0.613 0.696
  rs1997502 0.353 0.318 0.375 0.681
  rs2302612 0.119 0.157 0.199a 0.505
III rs1558626 0.446 0.488 0.313 0.108
  rs1345302 0.447 0.414 0.428 0.205
  rs1882510 0.224 0.229 0.919a 0.517
  rs1420089 0.154 0.151 1.000a 1.000
IL1RL1 rs1997466 0.476 0.427 0.250 0.385
  rs1041973 0.202 0.173 0.458a 0.202
  rs12905 0.274 0.235 0.293 0.366
IL18R1 rs2287037 0.383 0.416 0.433 0.461
  rs2270298 0.265 0.189 0.081a 0.131
  rs1035130 0.277 0.241 0.338 0.453
  rs1420096 0.466 0.458 0.868 0.746
IL18RAP rs1420106 0.192 0.200 0.832a 0.454
  rs1420100 0.469 0.447 0.599 1.000
  rs917997 0.189 0.185 1.000a 0.990
  1. MAF = Minor allele frequency in the sample set
  2. χ2 = p-values from Pearson's χ2 analysis of allele difference between cases and controls
  3. Pseudomarker = p-values of the family-based association analysis with Pseudomarker (dominant mode of inheritance)
  4. I, II and III = three intergenic regions
  5. a = calculated with Fisher's test
  6. b = p-value remained statistically significant after correcting for multiple testing