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Table 5 Of the SNPs Listed in Table 4, the SNPs Associated with Tuberculosis in This Study Population

From: Polymorphisms in IL-1β, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis

RS number

Gene

Minor Allele Frequency

Average Testing Balanced Accuracy

Cross-validation Consistency

P-value

Any TB vs. PPD+, all patients

Rs1811063

TNF-α

0.121

62.11#

4/5

0.05

Any TB vs. PPD+, black patients

Rs1399431

Rs7791836

TLR4

TNF-α

0.401

0.5

71.27^

3/5

0.02

  1. #Testing Sensitivity: 0.55; Testing Specificity: 0.69
  2. ^ Testing Sensitivity: 0.71; Testing Specificity: 0.72. In post-hoc logistic regression analysis using these 2 SNPs, a recessive encoding for each SNP maximized the model fit.
  3. The above are Multifactor Dimensionality Reduction models. Only models with P ≤ 0.05 are presented here.
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BMC Medical Genetics

ISSN: 1471-2350

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