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Table 5 Summary of NFE2L2 haplotypes that influence risk of PD

From: Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease

NFE2L2Haplotypes1 Swedish material Swedish material Polish material
  Disease Risk (OR/allele)2 p-value3 AAO
(Years/allele)
p-value3 Disease risk
(OR/allele)2
p-value3
Tag SNPs 2-6       
   GAAAA 0.9 (0.6-1.3) 0.450 +4.8 7 × 10 -4 0.6 (0.4-0.9) 0.005
   GAGGG 2.4 (1.2-4.5) 0.007 -0.1 0.952 0.9 (0.5-1.5) 0.699
   GAAAG 3.7 (1.3-10.6) 0.010 -3.3 0.236 0.5 (0.2-1.6) 0.239
Promoter P1-P3       
   AGC 0.9 (0.7-1.3) 0.538 +2.1 0.061 0.6 (0.4-0.9) 0.003
Full haplotypes 4       
   GAGCAAAA 0.9 (0.6-1.4) 0.631 +4.6 0.001 0.4 (0.3-0.6) 2 × 10 -6
   GAGAAGGG 2.8 (1.4-5.5) 0.002 -0.3 0.886 0.5 (0.3-1.0) 0.031
   GAGCAAAG 3.3 (1.1-9.7) 0.028 -2.5 0.387 0.4 (0.1-1.4) 0.150
  1. 1For rs-numbers see table 2. 2Data are given as OR (95% confidence interval). 3p values are calculated with logistic or linear regression models including the associated haplotypes and significantly relevant covariates in the specified windows. 4tag SNPs 2-6 and promoter SNPs P1-P3 in order according to chromosomal location (figure 1) with the promoter SNPs highlighted in bold.