Variable number of tandem repeat polymorphisms of the interleukin-1 receptor antagonist gene IL-1RN: a novel association with the athlete status

Table 6 Haplotype frequencies in athletes and non-athlete controls.

	Athletes (n = 205)	Controls (n = 458)	OR (95% CI)	P-value
Haplotype (3 sites) -511, +3954, IL-1RN)^a	Haplotype Frequency	Haplotype Frequency		0.012
C-C-L	0.360	0.406	1.0 (reference)	0.029
C-C-S	0.117	0.093	1.420 (0.862-2.339)	0.095
C-T-L	0.106	0.160	0.745 (0.436-1.274)	0.051
C-T-S	0.049	0.018	3.016 (1.156-7.867)	0.011
T-C-L	0.171	0.178	1.082 (0.711-1.648)	0.838
T-C-S	0.133	0.107	1.400 (0.891-2.200)	0.054
T-T-L	0.042	0.027	1.762 (0.692-4.487)	0.484
T-T-S	0.022	0.011	2.226 (0.492-10.080)	0.043
Haplotype (2 sites)
-511, +3954				0.264
C-C	0.478	0.498	1.0 (reference)	0.278
C-T	0.154	0.179	0.896 (0.608-1.321)	0.520
T-C	0.303	0.286	1.105 (0.815-1.498)	0.258
T-T	0.065	0.038	1.809 (0.889-3.679)	0.103
+3954, IL-1RN				0.001
C-L	0.529	0.584	1.0 (reference)	0.023
C-S	0.251	0.200	1.386 (1.013-1.897)	0.012
T-L	0.149	0.187	0.879 (0.597-1.292	0.183
T-S	0.071	0.029	2.658 (1.345-5.254)	0.003
-511, IL-1RN				0.003
C-L	0.465	0.566	1.0 (reference)	0.001
C-S	0.166	0.111	1.821 (1.213-2.732)	0.014
T-L	0.214	0.205	1.267 (0.894-1.795)	0.954
T-S	0.155	0.118	1.589 (1.099-2.298)	0.025

^aDue to the low allele frequencies of the 3, 4 and 5 alleles of the intron 2 VNTR IL-1RN genotypes were grouped into the short allele (S, allele 2) and the long alleles (L, alleles 1, 3, 4, and 5).

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