BMC Medical Genetics

Table 3 NFKB1 haplotypes and associations with colon and rectal cancer from hapConstructor and from multivariable-adjusted logistic regression

From: Exploring multilocus associations of inflammation genes and colorectal cancer risk using hapConstructor

			Genetic	hapConstructor*		Logistic regression**
SNP 1	SNP 2	Haplotype	Model	OR	P	OR	95%CI
Colon study
rs230510 A > T	rs4648110 T > A	2 copies A-A vs. 0/1 copy	Rec.	0.62	0.009	0.65	0.45, 0.95
rs13117745 C > T	rs4648110 T > A	2 copies T-A vs. 0 copies	Additive	0.62	0.009	0.65	0.44, 0.94
Rectal study
rs3821958 A > G	rs230510 A > T	2 copies A-T vs. 0 copies	Additive	0.66	0.006	0.68	0.50, 0.91
rs4648127 C > T	rs230510 A > T	2 copies C-T vs. 0 copies	Additive	0.66	0.006	0.68	0.50, 0.91
rs11722146 G > A	rs230510 A > T	2 copies G-T vs. 0 copies	Additive	0.66	0.006	0.67	0.50, 0.90
rs13117745 C > T	rs230510 A > T	2 copies C-T vs. 0 copies	Additive	0.66	0.006	0.67	0.50, 0.90
rs230510 A > T	rs4648090 G > A	2 copies T-G vs. 0 copies	Additive	0.67	0.007	0.68	0.51, 0.90
rs11722146 G > A	rs4648090 G > A	2 copies A-A vs. 0 copies	Additive	1.47	0.007	1.47	1.11, 1.93
rs230510 A > T	rs4648110 T > A	2 copies T-T vs. 0 copies	Additive	0.68	0.009	0.68	0.51, 0.91
rs3821958 A > G	rs4648110 T > A	2 copies G-A vs. 0 copies	Additive	1.52	0.005	1.49	1.12, 1.99
rs11722146 G > A	rs13117745 C > T	2 copies A-T vs. 0 copies	Additive	1.51	0.005	1.53	1.16, 2.01
rs11722146 G > A	rs4648127 C > T	2 copies A-T vs. 0 copies	Additive	1.33	0.004	1.36	1.12, 1.65
rs3821958 A > G	rs13117745 C > T	2 copies G-T vs. 0 copies	Additive	1.53	0.003	1.52	1.13, 2.02
rs11722146 G > A	rs4648110 T > A	2 copies A-A vs. 0 copies	Additive	1.54	0.0028	1.55	1.17, 2.04

NOTES: Odds ratio (OR); 95% confidence interval (95% CI); Recessive (Rec)
*adjusted for race
**adjusted for age, sex, center, and race; all P-trends (additive model) were significant, <0.01

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