The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project

Table 1 Studied SNPs

Gene	SNP		Minor allele frequency in controls			Linkage disequilibrium in controls
			North Europe	North Spain	Difference (p)	With	North Europe		North Spain
							D'	r ²	D'	r ²
DBH	rs1611115	-1021C/T	20.7% (T)	19.7% (T)	0.47	rs5320	0.994	0.015	0.994	0.017
	rs 5320	Exon 3 Ala197Thr	5.3% (A, Thr)	6.0% (A, Thr)	0.38	rs1611131	0.257	0.002	0.393	0.003
	rs1611131	Intron 10 A/G	29.4% (G)	24.5% (G)	0.002	rs1611115	0.295	0.055	0.250	0.047
IL1A	rs1800587	-889C/T	29.2% (T)	25.4% (T)	0.01	rs17561	0.999	0.994	0.989	0.971
	rs17561	Exon 5 Ala114Ser	29.2% (T, Ser)	25.6% (T, Ser)	0.02	rs3783550	0.997	0.185	0.999	0.145
	rs3783550	Intron 6 A/C	31.2% (C)	29.8% (C)	0.39	rs1800587	0.994	0.185	0.999	0.144
IL6	rs1800795	-174G/C	41.1% (C)	32.8% (C)	4 × 10 ^-7	rs2069837	0.999	0.055	0.998	0.049
	rs2069837	Intron 2 A/G	7.3% (G)	9.3% (G)	0.03

SNP = single nucleotide polymorphism, DBH = dopamine β-hydroxylase, IL1A = interleukin-lα, IL6 = interleukin-6, D' = ratio of observed linkage disequilibrium to maximum possible linkage disequilibrium, r ² = correlation coefficient.
Results in bold are significant at p < 0.05.

ISSN: 1471-2350