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Table 5 Significant associations of candidate gene polymorphisms and single-threshold albuminuriaa, additive genetic model

From: Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994

 

Crude Model

Fully AdjustedbModel

Variant

OR (95% CI)

P-value

FDR-adjusted P-value

OR (95% CI)

P-value

FDR-adjusted P-value

Non-Hispanic whites

      

rs1260326 (GCKR)

1.19 (0.92-1.53)

0.1774

0.8886

1.29 (1.02-1.64)

0.0361

0.6200

rs1800750 (TNF)

3.20 (2.06-4.98)

< 0.0001

< 0.0001

3.60 (1.65-7.88)

0.0025

0.1500

rs361525 (TNF)

1.71 (1.18-2.47)

0.0060

0.1800

1.94 (1.17-3.22)

0.0128

0.3840

rs2239185 (VDR)

0.81 (0.67-0.97)

0.0246

0.4020

0.84 (0.70-1.02)

0.0817

0.6200

rs731236 (VDR)

1.31 (1.03-1.65)

0.0268

0.4020

1.26 (0.99-1.61)

0.0612

0.6200

Non-Hispanic blacks

      

rs1205 (CRP)

0.75 (0.60-0.95)

0.0195

0.5655

0.74 (0.56-0.98)

0.0394

0.7760

rs3093058 (CRP)

0.74 (0.54-1.01)

0.0584

0.5942

0.72 (0.52-0.99)

0.0466

0.7760

rs1800468 (TGFB1/B9D2)

0.22 (0.06-0.76)

0.0193

0.5655

0.12 (0.01-0.99)

0.0493

0.7760

Mexican Americans

      

rs1800947 (CRP)

0.37 (0.08-1.77)

0.2022

0.6802

0.08 (0.03-0.20)

< 0.0001

< 0.0001

rs1143623 (IL1B)

1.30 (1.06-1.60)

0.0149

0.4321

1.55 (1.28-1.87)

0.0001

0.0029

rs1800871 (IL10)

1.24 (1.02-1.51)

0.0361

0.5234

1.14 (0.84-1.55)

0.3759

0.9181

rs1800872 (IL10)

1.25 (1.03-1.52)

0.0290

0.5234

1.15 (0.84-1.56)

0.3630

0.9181

rs1799983 (NOS3)

0.65 (0.39-1.10)

0.1046

0.6067

0.60 (0.37-0.98)

0.0423

0.4089

rs2070744 (NOS3)

0.66 (0.51-0.85)

0.0028

0.1624

0.62 (0.48-0.80)

0.0008

0.0155

rs1800629 (TNF)

0.75 (0.45-1.27)

0.2729

0.6914

0.65 (0.43-0.98)

0.0414

0.4089

  1. CI, confidence interval; FDR, false-discovery rate; OR, odds ratio.
  2. a) Defined as urinary albumin-to-creatinine ratio (ACR) above ≥ 30 mg/g regardless of gender. b) Analyses adjusted for age, sex, alcohol consumption, educational attainment, and waist:hip ratio.
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BMC Medical Genetics

ISSN: 1471-2350

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