Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994

Ned, Renée M; Yesupriya, Ajay; Imperatore, Giuseppina; Smelser, Diane T; Moonesinghe, Ramal; Chang, Man-huei; Dowling, Nicole F

doi:10.1186/1471-2350-11-155

Table 2 Weighted allele frequencies of polymorphisms examined in study participants, NHANES III DNA bank (1991-1994)

From: Inflammation gene variants and susceptibility to albuminuria in the U.S. population: analysis in the Third National Health and Nutrition Examination Survey (NHANES III), 1991-1994

				Non-Hispanic whites (N = 2249)		Non-Hispanic blacks (N = 1502)		Mexican Americans (N = 1570)
Gene	Variant	Type/location^a	Alleles	Frequency^b(%)	HWP P-value	Frequency (%)	HWP P-value	Frequency (%)	HWP P-value	P-value^c
ADRB2	rs1042713	Arg16Gly	A/G	38.7	0.4558	49.8	0.8106	40.7	0.3089	< 0.0001
	rs1042714	Gln27Glu	G/C	41.6	0.8470	17.7	0.5914	21.7	0.8367	< 0.0001
APOE	rs429358	Cys130Arg	C/T	15.1	0.4694	22.1	0.4997	10.9	0.0177	0.0002
	rs7412	Arg176Cys	T/C	8.2	0.7409	10.2	0.1013	3.5	0.4721	0.0004
CAT	rs769214	-843	G/A	33.9	0.8337	41.0	0.3725	50.2	0.4067	< 0.0001
CCL5	rs2280788	-95	G/C	3.0	0.0233	0.7	0.8085	1.2	0.6867	< 0.0001
CCR2	rs1799864	Val64Ile	A/G	9.5	0.3895	14.7	0.0828	22.0	0.8849	< 0.0001
CRP	rs1205	3'UTR	A/G	34.3	0.0620	21.1	0.0210	35.2	0.3485	< 0.0001
	rs1417938	intronic	T/A	29.9	0.4841	11.8	0.9060	34.1	0.2799	< 0.0001
	rs1800947	Leu184Leu	C/G	2.9	0.5732	0.8	0.7876	2.1	0.4574	0.0004
	rs2808630	downstream of gene	G/A	28.5	0.8126	16.8	0.2494	21.8	0.4448	< 0.0001
	rs3091244	-389	A/C	6.4	0.6077	26.3	0.7876	4.8	0.3901	< 0.0001
			T/C	30.6		27.8		35.7
	rs3093058	promoter	T/A	0.3	0.9146	15.9	0.8973	1.7	0.2351	< 0.0001
	rs3093066	3' UTR	A/C	0.7	0.7812	22.3	0.9172	1.5	0.5234	< 0.0001
	rs35500644	Thr35Thr	C/A	--^d		2.0	0.5503	--		0.0003
	rs11265260	upstream of gene	G/A	6.1	0.6833	7.1	0.6120	3.9	0.8988	0.0057
	rs12093699	downstream of gene	A/G	30.5	0.4361	31.7	0.4314	34.8	0.5947	0.0286
	rs12744244	downstream of gene	A/C	20.5	0.5659	4.3	0.2859	13.2	0.3447	< 0.0001
	rs2027471	upstream of gene	A/T	34.5	0.2198	22.6	0.0701	36.9	0.3717	< 0.0001
	rs2592887	downstream of gene	A/G	40.4	0.5556	49.0	0.9909	40.6	0.6631	< 0.0001
	rs2794520	downstream of gene	A/G	33.6	0.2538	22.8	0.0354	35.5	0.7546	< 0.0001
	rs3093075	downstream of gene	A/C	6.6	0.4684	26.2	0.9300	4.7	0.9636	< 0.0001
F2	rs1799963	upstream of gene	A/G	1.2	0.5214	0.3	0.8969	1.1	0.6927	0.0042
F5	rs6025	Arg534Gln	A/G	2.6	0.6247	0.6	0.8195	0.9	0.0101	< 0.0001
FCGR2A	rs1801274	His166Arg; His167Arg	G/A	51.1	0.0235	53.2	0.1480	52.9	0.9579	0.1412
FGB	rs1800790	-462	A/G	19.2	0.9227	5.5	0.0015	15.0	0.6910	< 0.0001
GCKR	rs1260326	Pro446Leu	T/C	43.3	0.3779	15.4	0.0016	34.2	0.3443	< 0.0001
IL1B	rs1143623	-2022	C/G	27.8	0.9893	11.0	0.6368	43.9	0.5735	< 0.0001
IL10	rs1800871	-853; -819	T/C	24.2	0.5168	39.3	0.9181	37.8	0.0123	< 0.0001
	rs1800872	-626; -592	A/C	24.4	0.4456	38.9	0.6244	37.7	0.0145	< 0.0001
	rs1800896	-1116; -1082	G/A	46.9	0.5030	35.6	0.3431	30.5	0.5009	< 0.0001
IL4	rs2243248	-1098	G/T	7.5	0.4678	15.6	0.6580	12.3	0.0577	< 0.0001
	rs2243250	-588; -524; -590	T/C	16.1	0.6836	64.7	0.1552	43.2	0.2281	< 0.0001
	rs2243270	intronic	G/A	16.5	0.5225	64.1	0.0082	42.7	0.2506	< 0.0001
IL4R	rs1801275	Gln576Arg	G/A	21.3	0.7231	67.7	< 0.0001	28.6	0.5716	< 0.0001
	rs1805015	Ser503Pro	C/T	16.3	0.6704	36.4	0.9842	15.5	0.2848	< 0.0001
ITGB3	rs5918	Leu59Pro	C/T	16.6	0.8121	9.8	0.9417	9.8	0.0677	< 0.0001
MBL2	rs11003125	-618; -550	G/C	35.8	0.8188	13.4	0.3698	51.3	0.4876	< 0.0001
	rs1800450	Gly54Asp	A/G	14.4	0.0333	3.5	0.0388	14.4	0.4665	< 0.0001
	rs1800451	Gly57Glu	A/G	2.1	0.1373	23.3	0.0131	2.8	0.2854	< 0.0001
	rs5030737	Arg52Cys	T/C	6.8	0.5280	1.0	0.7461	2.5	0.0514	< 0.0001
	rs7096206	-289; -221	C/G	22.5	0.2505	14.9	0.6554	11.0	0.0133	< 0.0001
NOS2A	rs1800482	promoter	C/G	--		6.7	0.4602	0.3	< 0.0001	< 0.0001
	rs9282799	-2892; -1173	T/C	0.0	0.9579	4.5	0.5776	0.2	0.9494	< 0.0001
NOS3	rs1799983	Asp298Glu	T/G	32.6	0.3242	13.2	0.1706	19.4	0.1261	< 0.0001
	rs2070744	-786	C/T	39.2	0.5881	15.6	0.0190	24.2	0.0251	< 0.0001
PON1	rs662	Gln192Arg	G/A	32.2	0.5369	67.3	0.9505	46.6	0.1891	< 0.0001
	rs854560	Leu55Met	A/T	35.2	0.3791	18.0	0.4022	22.7	0.7799	< 0.0001
PPARG	rs1801282	Pro12Ala	G/C	13.5	0.9051	2.7	0.9100	12.3	0.5137	< 0.0001
SERPINE1	rs1799762	ins/del in promoter	4G/5G	53.0	0.6712	26.7	0.2376	33.5	0.4660	< 0.0001
TGFB1/B9D2	rs1800468	-800	A/G	7.8	0.8588	2.9	0.8929	5.0	0.6573	< 0.0001
	rs1800469	-509	T/C	31.6	0.7314	24.6	0.8500	44.2	0.2589	< 0.0001
	rs1800470	Pro10Leu	C/T	38.7	0.2483	45.8	0.5523	49.7	0.0675	< 0.0001
TLR4	rs4986790	Asp299Gly	G/A	6.6	0.2370	7.2	0.5877	2.6	0.2387	< 0.0001
TNF	rs1800629	-487; -308	A/G	17.1	0.4636	12.6	0.6949	6.9	0.8989	< 0.0001
	rs1800750	-555	A/G	1.5	< 0.0001	2.4	0.1562	2.7	0.2652	0.0326
	rs361525	-417; -238	A/G	5.9	0.0156	3.8	0.8423	5.9	0.2594	0.0040
VDR	rs2239185	intronic	C/T	47.9	0.0008	43.5	0.6865	58.6	0.7644	< 0.0001
	rs731236	Ile352Ile; TaqI	C/T	38.2	0.2444	28.7	0.5501	23.8	0.2615	< 0.0001
Unknown	rs890945	unknown	A/T	20.8	0.5772	29.6	0.2610	29.9	0.8995	< 0.0001

HWP, Hardy-Weinberg proportions; NHANES III, Third National Health and Nutrition Examination Survey.
a) Alternate designations are given, if available. b) Weighted frequencies are presented for the first listed allele. c) Chi-square test of significance of the difference in allele frequency across race/ethnic groups. d) Cannot report due to disclosure concerns (small cell sizes).

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