Suggestive evidence of associations between liver X receptor β polymorphisms with type 2 diabetes mellitus and obesity in three cohort studies: HUNT2 (Norway), MONICA (France) and HELENA (Europe)

Table 3 Genotype distribution for the 5 LXRβ; SNPs in obese and non obese individuals from the MONICA study and ORs [95% CI] of obesity.

	Genotype	Non obese (n = 1945)		Obese (n = 373)		Crude p	Adjusted OR	[95% CI]	Adjusted p
		n	Frequency	n	Frequency
rs17373080	CC	937	0.48	157	0.43
	CG	804	0.42	166	0.45	0.13	1.26	[1.00-1.59]	0.05
	GG	191	0.10	43	0.12
	Total	1932		366
rs56151148	CC	1595	0.83	314	0.85
	CT	325	0.17	53	0.14	0.46^a	0.78	[0.57-1.08]	0.13
	TT	11	0.01	1	0.00
	Total	1931		368
rs2695121	CC	616	0.32	128	0.35
	CT	947	0.49	182	0.49	0.30	0.90	[0.71-1.14]	0.39
	TT	370	0.19	59	0.16
	Total	1933		369
rs2303044	CC	1658	0.85	308	0.83
	CT	262	0.14	60	0.16	0.41^a	1.23	[0.91-1.67]	0.18
	TT	20	0.01	3	0.01
	Total	1940		371
rs3219281	CC	1571	0.83	305	0.82
	CT	310	0.16	61	0.16	0.77^a	1.03	[0.76-1.39]	0.85
	TT	19	0.01	5	0.01
	Total	1900		371

^aFisher exact test. ORs and p values were adjusted for age, gender, centre, smoking habit, alcohol consumption and physical activity level. A dominant model was used to calculate the odds ratios. Significant p values are indicated in bold.

ISSN: 1471-2350