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Table 4 Genotype associations (P < 0.05) among subgroups under different modes of inheritance

From: Genes encoding critical transcriptional activators for murine neural tube development and human spina bifida: a case-control study

Marker

Gene

Ethnicity

P value

Mode of Inheritance

Odds Ratio

[(ratio count (case, control))

95% CI

rs17002284

EP300

All subjects

0.012

Recessive

0.43 (13, 29; 284, 271)

0.22 - 0.84

rs4820428

EP300

All subjects

0.011

Additive [(Dd) vs (dd)]

1.46 (132, 122; 87, 117)

1.00 - 2.11

    

   [(DD) vs (Dd)]

1.18 (78, 61; 132, 122)

0.78 - 1.79

  

All subjects

0.012

Dominant

1.54 (210, 183; 87, 117)

1.10 - 2.17

rs4820429

EP300

All subjects

0.046

Dominant

0.70 (75, 98; 222, 202)

0.49 - 0.99

  

White

0.041

Dominant

0.50 (22, 52; 37, 44)

0.26 - 0.50

rs1621700

TFAP2A

All subjects

0.041

Additive [(Dd) vs (dd)]

1.30 (131, 118; 138, 161)

0.92 - 1.81

    

   [(DD) vs (Dd)]

1.33 (28, 19; 131, 118)

0.70 - 2.50

rs3798691

TFAP2A

Hispanic

0.015

Additive [(Dd) vs (dd)]

1.78 (48, 23; 143, 122)

1.04 - 3.19

    

   [(DD) vs (Dd)]

1.40 (9, 3; 47, 22)

0.35 - 5.70

  

Hispanic

0.022

Dominant

1.84 (56, 26; 143, 122)

1.13 - 3.25

  

Hispanic-FB

0.049

Dominant

1.82 (44, 19; 122, 92)

1.00 - 3.40

rs533558

TFAP2A

Hispanic-NB

0.038

Additive [(Dd) vs (dd)]

3.00 (18, 14; 6, 14)

0.92 - 9.80

    

   [(DD) vs (Dd)]

1.40 (9, 5; 18, 14)

0.38 - 5.12

  

Hispanic-NB

0.032

Dominant

3.32 (27, 19; 6, 14)

1.08 - 10.18

rs17616105

CARM1

Hispanic

0.0

Recessive

n/a (6, 0; 193, 148)

n/a

  

White

0.004

Additive [(Dd) vs (dd)]

0.48 (15, 36; 43,50)

0.23 - 1.00

    

   [(DD) vs (Dd)]

0.24 (1,10; 15,36)

0.03 - 2.04

  

White

0.010

Dominant

0.40 (16, 46; 43, 50)

0.40 - 0.20

rs1131431

CITED2

White

0.027

Recessive

5.32 (6, 2; 53, 94)

1.04 - 27.30

rs129986

CREBBP

All subjects

0.005

Additive [(Dd) vs (dd)]

0.27 (6, 21; 291, 279)

0.11 - 0.69

    

   [(DD) vs (Dd)]

n/a (0, 0; 6, 21)

n/a

  

All subjects

0.003

Dominant

0.27 (6, 21; 291, 279)

0.11 - 0.69

  

White

0.014

Additive [(Dd) vs (dd)]

n/a (0, 10; 59, 86)

n/a

    

   [(DD) vs (Dd)]

n/a (0, 0; 0, 10)

n/a

  

White

0.010

Dominant

n/a (0, 10; 59, 86)

n/a

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BMC Medical Genetics

ISSN: 1471-2350

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