Haplotype structure of the COL7A1 gene locus in Europeans. (A) Structure of the COL7A1 gene with positions of SNPs by the Hap Map project. Haploview-generated linkage disequilibrium (LD) patterns of the COL7A1 gene and predicted block structure in Caucasian control subjects. Rate (D') of LD is represented by different colors (highest rate of LD in red, lower LD in purple, and white for no LD). (B) Potential haplotypes in the European population for six selected SNPs that have been genotyped in our study.