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Table 3 SLC2A10 haplotype analysis for association with baseline, incident, and all PAD in type 2 diabetes.

From: SLC2A10 genetic polymorphism predicts development of peripheral arterial disease in patients with type 2 diabetes. SLC2A10and PAD in type 2 diabetes

  Haplotype Sequence Frequency Baseline PAD association Incident PAD association
    P * OR (95% CI)* P * HR (95%CI)*
H1 A3TAGCCTTTT 0.051 0.87 1.28(0.07-22.8) 0.89 1.17(0.13-10.4)
H2 G3CTGTGCCCC 0.499 0.01 0.20(0.05- 0.75) 0.80 1.20(0.30- 4.72)
H3 G2TAGCCTTTT 0.118 0.08 4.20(0.82- 21.6) 0.29 0.42(0.09- 2.06)
H4 G3TAGCCTTTT 0.063 0.03 14.5(1.3-160) 0.007 6.78(1.66- 27.6)
H5 G2CAACCTTTT 0.041 0.97 1.07(0.04- 29.5) 0.99 1.8 × 10-7 (0-∞)
H6 G2CTGTGCCCC 0.026 0.42 5.4 × 10-4(0- 40159) 0.66 0.60(0.06-5.99)
H7 G3TAGCCTTTC 0.023 0.48 1.7 × 10-6 (0-∞) 0.87 1.22(0.10- 14.5)
H8 G3CTGTGCCCT 0.015 0.40 7.67(0.07- 894) 0.34 3.01(0.31- 29.0)
Rare haplotypes 0.15 0.26 1.36(0.80-2.31) 0.99 4.8 × 10-6 (0-∞)
  1. * P-values, odds ratios, and hazard ratios were adjusted for covariates including age, sex, duration of diabetes, body mass index, triglyceride, total cholesterol, hemoglobin A1C, systolic blood pressure and current smoking status.
  2. PAD, peripheral artery disease; OR, odds ratio; HR, hazard ratio, CI, confidence interval