Genetic polymorphisms in MDR1, CYP3A4 and CYP3A5 genes in a Ghanaian population: a plausible explanation for altered metabolism of ivermectin in humans?

Table 2 Allele and Genotype frequencies for the MDR1 and CYP3A observed in IVM treated subjects (%, 95% CI in parenthesis)

	MDR1 3435C > T		CYP3A4*1B		CYP3A5*3		CYP3A5*6
	RES	SOR	RES	SOR	RES	SOR	RES	SOR
Total no genotyped	21	21	21	21	21	21	21	21
Major allele	16	12	3	1	9	13	18	17
homozygous	(76, 57.3 - 94.3)	(57, 35.9 - 78.2)	(14, -0.8 - 28.8)	(5, -4.3 - 14.3)	(43, 21.8 - 64.2)	(62, 41.2 - 82.8)	(86, 71.2 - 100)	(81, 62.4 - 97.8)
Heterozygous	5	9	11	11	11	7	3	3
	(24, 5.7 - 42.3)	(43, 21.8 - 64.2)	(53, 31.7 - 74.4)	(52, 3.6 - 73.4)	(52, 30.6 - 73.4)	(33, 12.9 - 53.1)	(14, -0.8 - 28.8)	(14, -0.8 - 28.8)
Minor allele	0	0	7	9	1	1	0	1
homozygous			(33, 12.9 - 53.1)	(43, 21.8 - 64.2)	(5, -4.3 - 14.3)	(5, -4.3 - 14.3)		(5, -4.3 - 14.3)
Major allele	18	17	8	14	14	17	20	18
frequency	(88, 74.1 - 101)	(79, 61.6 - 96.4)	(40, 19.1 - 61)	(69, 49.2 - 88.8)	(69, 49.2 - 88.8)	(79, 61.6 - 96.4)	(93, 82.1 - 103	(88, 74.1 - 101)
Minor allele	3	4	13	7	7	4	1	3
frequency	(12, -1.9 - 25.9)	(21, 3.6 - 38.4)	(60, 30.1 - 81)	(31, 11.2 - 50.8)	(31, 11.2 - 50.8)	(21, 3.6 - 38.4)	(7, -3.9 - 17.9)	(12, -1.9 - 25.9)

CI, Confidence interval. MDR1 (1236C > T), MDR1 (2677G > A), MDR1 (2677G > T), CYP3A4*3 variant alleles were not detected in this study population

ISSN: 1471-2350