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Table 2 Allele and Genotype frequencies for the MDR1 and CYP3A observed in IVM treated subjects (%, 95% CI in parenthesis)

From: Genetic polymorphisms in MDR1, CYP3A4 and CYP3A5 genes in a Ghanaian population: a plausible explanation for altered metabolism of ivermectin in humans?

  MDR1 3435C > T CYP3A4*1B CYP3A5*3 CYP3A5*6
  RES SOR RES SOR RES SOR RES SOR
Total no genotyped 21 21 21 21 21 21 21 21
Major allele 16 12 3 1 9 13 18 17
homozygous (76, 57.3 - 94.3) (57, 35.9 - 78.2) (14, -0.8 - 28.8) (5, -4.3 - 14.3) (43, 21.8 - 64.2) (62, 41.2 - 82.8) (86, 71.2 - 100) (81, 62.4 - 97.8)
Heterozygous 5 9 11 11 11 7 3 3
  (24, 5.7 - 42.3) (43, 21.8 - 64.2) (53, 31.7 - 74.4) (52, 3.6 - 73.4) (52, 30.6 - 73.4) (33, 12.9 - 53.1) (14, -0.8 - 28.8) (14, -0.8 - 28.8)
Minor allele 0 0 7 9 1 1 0 1
homozygous    (33, 12.9 - 53.1) (43, 21.8 - 64.2) (5, -4.3 - 14.3) (5, -4.3 - 14.3)   (5, -4.3 - 14.3)
Major allele 18 17 8 14 14 17 20 18
frequency (88, 74.1 - 101) (79, 61.6 - 96.4) (40, 19.1 - 61) (69, 49.2 - 88.8) (69, 49.2 - 88.8) (79, 61.6 - 96.4) (93, 82.1 - 103 (88, 74.1 - 101)
Minor allele 3 4 13 7 7 4 1 3
frequency (12, -1.9 - 25.9) (21, 3.6 - 38.4) (60, 30.1 - 81) (31, 11.2 - 50.8) (31, 11.2 - 50.8) (21, 3.6 - 38.4) (7, -3.9 - 17.9) (12, -1.9 - 25.9)
  1. CI, Confidence interval. MDR1 (1236C > T), MDR1 (2677G > A), MDR1 (2677G > T), CYP3A4*3 variant alleles were not detected in this study population