Genetic polymorphisms in MDR1, CYP3A4 and CYP3A5 genes in a Ghanaian population: a plausible explanation for altered metabolism of ivermectin in humans?

Table 1 Allele and Genotype frequencies for the MDR1 and CYP3A observed in Ghanaian population (%, 95% CI in parenthesis)

	MDR1 3435C > T	CYP3A4*1B	CYP3A5*3	CYP3A5*6
Total no genotyped	194	203	200	194
Major allele	153	15	141	141
homozygous	(78.9, 73.1 - 84.6)	(7.4, 3.79 - 11.0)	(70.5, 64.1 - 76.8)	(72.7, 66.4 - 79.0)
Heterozygous	38	86	58	51
	(19.6, 14 - 25.2)	(42.4, 35.6 - 49.2)	(29, 22.7 - 35.3)	(26.3, 20.1 - 32.5)
Minor allele	3	102	1	2
homozygous	(1.6, -0.19 - 3.3)	(50.3, 43.4 - 57.1)	(0.05, -0.5 - 1.5)	(1.03, -0.4 - 2.5)
Major allele	89	28	85	86
frequency	(84.6 - 93.4)	(21.8 - 34.2)	(80.1 - 90.0)	(81.1 - 90.9)
Minor allele	11	72	15	14
frequency	(6.6 - 15.4)	(65.8 - 78.2)	(10.1 - 20.0)	(9.1 - 18.9)

CI, Confidence interval. MDR1 (1236C > T), MDR1 (2677G > A), MDR1 (2677G > T), CYP3A4*3 variant alleles were not detected in this study population

ISSN: 1471-2350