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Table 1 Allele and Genotype frequencies for the MDR1 and CYP3A observed in Ghanaian population (%, 95% CI in parenthesis)

From: Genetic polymorphisms in MDR1, CYP3A4 and CYP3A5 genes in a Ghanaian population: a plausible explanation for altered metabolism of ivermectin in humans?

  MDR1 3435C > T CYP3A4*1B CYP3A5*3 CYP3A5*6
Total no genotyped 194 203 200 194
Major allele 153 15 141 141
homozygous (78.9, 73.1 - 84.6) (7.4, 3.79 - 11.0) (70.5, 64.1 - 76.8) (72.7, 66.4 - 79.0)
Heterozygous 38 86 58 51
  (19.6, 14 - 25.2) (42.4, 35.6 - 49.2) (29, 22.7 - 35.3) (26.3, 20.1 - 32.5)
Minor allele 3 102 1 2
homozygous (1.6, -0.19 - 3.3) (50.3, 43.4 - 57.1) (0.05, -0.5 - 1.5) (1.03, -0.4 - 2.5)
Major allele 89 28 85 86
frequency (84.6 - 93.4) (21.8 - 34.2) (80.1 - 90.0) (81.1 - 90.9)
Minor allele 11 72 15 14
frequency (6.6 - 15.4) (65.8 - 78.2) (10.1 - 20.0) (9.1 - 18.9)
  1. CI, Confidence interval. MDR1 (1236C > T), MDR1 (2677G > A), MDR1 (2677G > T), CYP3A4*3 variant alleles were not detected in this study population