Table 3 Additive model study-specific and meta-analysis results
From: Genomewide association study for onset age in Parkinson disease
| Â | GenePD-PROGENI | Mayo-Perlegen LEAPS | GWAS Meta-analysis | Milan, Italian | Three Sample Meta-analysis | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
SNP | effect | p-value | effect | p-value | Direction of Effect | effect | p-value | effect | p-value | Direction of Effect | effect | p-value |
rs17565841 | -4.66 | 2.7 × 10-6 | -3.64 | 1.7 × 10-1 | -- | -4.53 | 9.1 × 10-7 | -1.57 | 5.0 × 10-2 | --- | -2.84 | 2.6 × 10-6 |
rs10918270 | -2.12 | 1.1 × 10-4 | -1.90 | 1.6 × 10-2 | -- | -2.05 | 4.8 × 10-6 | -0.62 | 2.7 × 10-1 | --- | -1.49 | 2.0 × 10-5 |
rs12261736 | -3.61 | 1.8 × 10-7 | -1.17 | 4.0 × 10-1 | -- | -3.13 | 3.5 × 10-7 | -0.42 | 4.5 × 10-1 | --- | -1.65 | 6.6 × 10-5 |
rs4771006 | 2.35 | 1.6 × 10-3 | 2.59 | 1.6 × 10-3 | ++ | 2.46 | 7.3 × 10-6 | 0.50 | 3.8 × 10-1 | +++ | 1.52 | 1.2 × 10-4 |
rs1420143 | 2.08 | 1.4 × 10-4 | 2.58 | 8.1 × 10-3 | ++ | 2.20 | 3.6 × 10-6 | 0.02 | 9.8 × 10-1 | +++ | 1.27 | 4.1 × 10-4 |
rs6936388 | 2.45 | 4.2 × 10-4 | 2.98 | 7.2 × 10-3 | ++ | 2.60 | 9.2 × 10-6 | -0.31 | 7.0 × 10-1 | ++- | 1.58 | 8.2 × 10-4 |
rs10147486 | 2.21 | 3.1 × 10-4 | 2.89 | 8.0 × 10-4 | ++ | 2.44 | 9.2 × 10-7 | -0.69 | 3.0 × 10-1 | ++- | 1.31 | 9.5 × 10-4 |
rs7076519 | -2.71 | 9.3 × 10-6 | -2.53 | 2.5 × 10-2 | -- | -2.67 | 6.0 × 10-7 | 0.68 | 1.8 × 10-1 | --+ | -0.92 | 1.3 × 10-2 |