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Table 4 Association analysis of INSIG2 rs7566605 with the levels of cholesterol and triglyceride

From: Association analyses of the INSIG2polymorphism in the obesity and cholesterol levels of Korean populations

   

n (mean ± SD)

Group

Phenotype

MAF

G/G

G/C

C/C

Kirin

Total

Total cholesterol

0.35

389(4.76 ± 1.42)

395(5.12 ± 1.77)

122(4.76 ± 1.36)

   

P ANOVA = 0.00250, P dom = 0.0134, P rec = 0.155

 

HDL cholesterol

0.35

341(1.61 ± 0.907)

328(1.64 ± 0.970)

111(1.42 ± 0.701)

   

P ANOVA = 0.0969, P dom = 0.764, P rec = 0.0352

 

Triglyceride

0.35

394(1.03 ± 0.567)

398(0.968 ± 0.597)

122(1.09 ± 0.708)

   

P ANOVA = 0.0415, P dom = 0.117, P rec = 0.186

Female

Total cholesterol

0.35

362(4.78 ± 1.44)

367(5.14 ± 1.78)

111(4.74 ± 1.34)

   

P ANOVA = 0.00410, P dom = 0.0170, P rec = 0.178

 

HDL cholesterol

0.35

314(1.64 ± 0.904)

300(1.61 ± 0.896)

100(1.41 ± 0.618)

   

P ANOVA = 0.0647, P dom = 0.265, P rec = 0.0203

 

Triglyceride

0.35

368(0.996 ± 0.537)

370(0.910 ± 0.455)

111(1.02 ± 0.613)

   

P ANOVA = 0.0396, P dom = 0.0877, P rec = 0.235

Male

Total cholesterol

0.38

27(4.54 ± 1.10)

28(4.89 ± 1.65)

11(4.56 ± 1.47)

   

P ANOVA = 0.629, P dom = 0.480, P rec = 0.728

 

HDL cholesterol

0.39

27(1.30 ± 0.891)

28(1.95 ± 1.54)

11(1.62 ± 1.30)

   

P ANOVA = 0.168, P dom = 0.0804, P rec = 0.984

 

Triglyceride

0.38

26(1.57 ± 0.708)

28(1.73 ± 1.33)

11(1.67 ± 1.26)

   

P ANOVA = 0.892, P dom = 0.716, P rec = 0.875

Yeungnam

Total

Total cholesterol

0.35

312 (5.35 ± 0.913)

329 (5.37 ± 0.986)

93(5.39 ± 1.03)

   

P ANOVA = 0.930, P dom = 0.751, P rec = 0.760

 

HDL cholesterol

0.35

312 (1.36 ± 0.336)

329 (1.38 ± 0.360)

93(1.37 ± 0.333)

   

P ANOVA = 0.771, P dom = 0.509, P rec = 0.954

 

Triglyceride

0.35

312 (1.83 ± 1.33)

329 (1.81 ± 1.54)

93(1.75 ± 0.996)

   

P ANOVA = 0.802, P dom = 0.675, P rec = 0.726

Female

Total cholesterol

0.34

121(5.22 ± 0.855)

119(5.39 ± 1.04)

34(5.44 ± 1.09)

   

P ANOVA = 0.296, P dom = 0.124, P rec = 0.445

 

HDL cholesterol

0.34

121(1.49 ± 0.343)

119(1.47 ± 0.357)

34(1.51 ± 0.323)

   

P ANOVA = 0.813, P dom = 0.755, P rec = 0.670

 

Triglyceride

0.34

121(1.46 ± 1.20)

119(1.37 ± 0.883)

34(1.38 ± 0.609)

   

P ANOVA = 0.784, P dom = 0.610, P rec = 0.781

Male

Total cholesterol

0.36

191 (5.43 ± 0.943)

210 (5.35 ± 0.956)

59 (5.36 ± 1.01)

   

P ANOVA = 0.703, P dom = 0.402, P rec = 0.833

 

HDL cholesterol

0.36

191 (1.28 ± 0.307)

210 (1.33 ± 0.353)

59 (1.29 ± 0.316)

   

P ANOVA = 0.275, P dom = 0.173, P rec = 0.716

 

Triglyceride

0.36

191 (2.06 ± 1.36)

210 (2.06 ± 1.77)

59 (1.96 ± 1.11)

   

P ANOVA = 0.857, P dom = 0.664, P rec = 0.850

Multicenter

Total

Total cholesterol

0.34

258(4.80 ± 0.818)

277(4.80 ± 0.804)

63(4.97 ± 0.798)

   

P ANOVA = 0.273, P dom = 0.660, P rec = 0.107

 

HDL cholesterol

0.34

258(0.884 ± 0.818)

277(1.15 ± 0.293)

64(1.19 ± 0.325)

   

P ANOVA = 0.870, P dom = 0.625, P rec = 0.965

 

Triglyceride

0.34

258(1.31 ± 0.949)

277(1.35 ± 0.904)

63(1.15 ± 0.639)

   

P ANOVA = 0.288, P dom = 0.988, P rec = 0.133

Female

Total cholesterol

0.35

159(4.81 ± 0.798)

179(4.81 ± 0.819)

46(5.03 ± 0.780)

   

P ANOVA = 0.216, P dom = 0.560, P rec = 0.0801

 

HDL cholesterol

0.35

159(0.883 ± 0.0539)

179(0.883 ± 0.0972)

47(0.879 ± 0.0161)

   

P ANOVA = 0.943, P dom = 0.894, P rec = 0.733

 

Triglyceride

0.35

159(1.18 ± 0.764)

179(1.12 ± 0.646)

46(0.99 ± 0.429)

   

P ANOVA = 0.244, P dom = 0.214, P rec = 0.144

Male

Total cholesterol

0.31

99(4.79 ± 0.852)

98(4.77 ± 0.779)

17(4.81 ± 0.845)

   

P ANOVA = 0.978, P dom = 0.916, P rec = 0.883

 

HDL cholesterol

0.31

99(0.884 ± 0.0559)

98(0.876 ± 0.0185)

17(0.892 ± 0.102)

   

P ANOVA = 0.336, P dom = 0.389, P rec = 0.359

 

Triglyceride

0.31

99(1.52 ± 1.16)

98(1.77 ± 1.13)

17(1.57 ± 0.895)

   

P ANOVA = 0.300, P dom = 0.157, P rec = 0.817

  1. The P values for the levels of cholesterol and triglyceride in subjects with minor alleles were assessed by an ANOVA for a difference among three genotypes or by a T-test for the dominant and recessive models. The significant threshold was 0.0015 for the Kirin population (11 phenotypes and 3 different models) and 0.0033 for the Yeungnam and Multicenter populations (5 phenotypes and 3 different models).
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BMC Medical Genetics

ISSN: 1471-2350

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