Table 1 Results of dopamine-related genes association studies
From: Two-stage case-control association study of dopamine-related genes and migraine
A. Significant results of the association study of 50 SNPs from eight dopamine-related genes in population 1 (patients N = 263, controls N = 274) and results of the analysis of these markers in population 2 (patients N = 259, controls N = 287). | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cases | Controls | Genotype 11 vs 12+22 | Genotype 11+12 vs 22 | Allele 2 vs allele 1 | ||||||||||||
Gene | SNP population | 11 | 12 | 22 | Sum | 11 | 12 | 22 | Sum | P value | OR (95% IC) | P value | OR (95% IC) | P value | OR (95% IC) | P value |
DRD1 | rs251937 p1 | 133 (54.7) | 95 (39.1) | 15 (6.2) | 243 | 120 (45.5) | 119 (45.1) | 25 (9.4) | 264 | NS | 1.45a (1.02-2.08) | 0.0355 | 1.58a (0.82-3.12) | NS | 1.36 (1.04-1.79) | 0.0261 |
p2 | 130 (53.0) | 95 (38.8) | 20 (8.2) | 245 | 144 (51.8) | 116 (41.7) | 18 (6.5) | 278 | NS | 1.05a (0.74-1.49) | NS | 1.29 (0.66-2.51) | NS | 1.01a (0.77-1.33) | NS | |
DRD2 | rs12363125 p1 | 133 (51.8) | 97 (37.7) | 27 (10.5) | 257 | 108 (40.6) | 128 (48.1) | 30 (11.3) | 266 | 0.0304 | 1.56a (1.11-2.22) | 0.0102 | 1.07a (0.62-1.85) | NS | 1.31 (1.01-1.70) | 0.0401 |
p2 | 112 (43.6) | 123 (47.9) | 22 (8.5) | 257 | 141 (49.5) | 112 (39.3) | 32 (11.2) | 285 | NS | 1.27 (0.90-1.78) | NS | 1.35a (0.76-2.38) | NS | 1.07 (0.83-1.39) | NS | |
DRD2 | rs2283265 p1 | 210 (82.4) | 44 (17.3) | 1 (0.3) | 255 | 196 (72.3) | 69 (25.5) | 6 (2.2) | 271 | 0.0085 | 1.79a (1.18-2.70) | 0.0059 | 5.88a (0.68-50) | NS | 1.78 (1.20-2.63) | 0.0030* |
p2 | 199 (77.7) | 54 (21.1) | 3 (1.2) | 256 | 226 (81.3) | 49 (17.6) | 3 (1.1) | 278 | NS | 1.24 (0.81-1.89) | NS | 1.09 (0.22-4.46) | NS | 1.2a (0.81-1.77) | NS | |
DRD3 | rs3732790 p1 | 113 (44.0) | 119 (46.3) | 25 (9.7) | 257 | 104 (38.7) | 115 (42.7) | 50 (18.6) | 269 | 0.0131 | 1.25a (0.88-1.75) | NS | 2.12a (1.27-3.57) | 0.0033 | 1.36 (1.06-1.75) | 0.0169 |
p2 | 101 (39.5) | 122 (47.7) | 33 (12.8) | 256 | 114 (40.3) | 125 (44.2) | 44 (15.5) | 283 | NS | 1.03 (0.73-1.46) | NS | 1.25a (0.76-2.04) | NS | 1.04 (0.81-1.33) | NS | |
DBH | rs1611131 p1 | 129 (56.6) | 76 (33.3) | 23 (10.1) | 228 | 129 (49.6) | 114 (43.8) | 17 (6.6) | 260 | 0.0400 | 1.33a (0.93-1.92) | NS | 1.57 (0.81-3.02) | NS | 1.09 (0.83-1.47) | NS |
p2 | 124 (51.0) | 102 (42.0) | 17 (7.0) | 243 | 136 (52.7) | 107 (41.5) | 15 (5.8) | 258 | NS | 1.07 (0.76-1.52) | NS | 1.22 (0.60-2.50) | NS | 1.08a (0.82-1.42) | NS | |
TH | rs2070762 p1 | 51 (20.8) | 138 (56.3) | 56 (22.9) | 245 | 84 (32.2) | 129 (49.4) | 48 (18.4) | 261 | 0.0130 | 1.81 (1.21-2.72) | 0.0035* | 1.32 (0.85-2.03) | NS | 1.37a (1.08-1.75) | 0.0111 |
p2 | 57 (23.4) | 119 (49.0) | 67 (27.6) | 243 | 78 (28.2) | 131 (47.3) | 68 (24.5) | 277 | NS | 1.28 (0.86-1.90) | NS | 1.17 (0.79-1.74) | NS | 1.16a (0.92-1.49) | NS | |
B. Results of the association study of DRD2 rs2283265 and TH rs2070762 in the migraine without aura and migraine with aura subgroups of population 1 and population 2. | ||||||||||||||||
Cases | Controls | Genotype 11 vs 12+22 | Genotype 11+12 vs 22 | Allele 2 vs allele 1 | ||||||||||||
Gene | SNP population | 11 | 12 | 22 | Sum | 11 | 12 | 22 | Sum | P value | OR (95% IC) | P value | OR (95% IC) | P value | OR (95% IC) | P value |
Migraine without aura | ||||||||||||||||
DRD2 | rs2283265 p1 | 119 (82.6) | 25 (17.4) | 0 (0.0) | 144 | 196 (72.3) | 69 (25.5) | 6 (2.2) | 271 | 0.0097 | 1.81a (1.10-3.03) | 0.017 | 1.02 (1.004-1.04) | 0.023 | 1.85 (1.15-2.90) | 0.0081 |
p2 | 115 (72.8) | 40 (25.3) | 3 (1.9) | 158 | 226 (81.3) | 49 (17.6) | 3 (1.1) | 278 | NS | 1.59 (1.00-2.53) | NS | 1.80 (0.36-9.05) | NS | 1.52a (1.00-2.32) | NS | |
TH | rs2070762 p1 | 27 (19.0) | 84 (59.2) | 31 (21.8) | 142 | 84 (32.2) | 129 (49.4) | 48 (18.4) | 261 | 0.0143 | 2.04 (1.24-3.34) | 0.0036 | 1.24 (0.74-2.05) | NS | 1.40a (1.04-1.88) | 0.023 |
p2 | 37 (24.5) | 73 (48.3) | 41 (27.2) | 151 | 78 (28.2) | 131 (47.3) | 68 (24.5) | 277 | NS | 1.19 (0.76-1.88) | NS | 1.11 (0.71-1.76) | NS | 1.11a (0.84-1.47) | NS | |
Migraine with aura | ||||||||||||||||
DRD2 | rs2283265 p1 | 91 (82.0) | 19 (17.1) | 1 (0.9) | 111 | 196 (72.3) | 69 (25.5) | 6 (2.2) | 271 | NS | 1.75a (1.00-3.03) | 0.042 | 2.5a (0.29-20.0) | NS | 1.69 (1.01-2.77) | 0.037 |
p2 | 84 (85.7) | 14 (14.3) | 0 (0.0) | 98 | 226 (81.3) | 49 (17.6) | 3 (1.1) | 278 | NS | 1.37a (0.72-2.56) | NS | 1.01a (0.99-1.02) | NS | 1.41 (0.77-2.63) | NS | |
TH | rs2070762 p1 | 24 (23.3) | 54 (52.4) | 25 (24.3) | 103 | 84 (32.2) | 129 (49.4) | 48 (18.4) | 261 | NS | 1.57 (0.93-2.66) | NS | 1.44 (0.83-2.5) | NS | 1.35a (0.98-1.89) | NS |
p2 | 20 (21.7) | 46 (50.0) | 26 (28.3) | 92 | 78 (28.2) | 131 (47.3) | 68 (24.5) | 277 | NS | 1.44 (0.82-2.52) | NS | 1.28 (0.75-2.20) | NS | 1.26a (0.90-1.75) | NS | |