Figure 4

Specificity and sensitivity of an algorithm for segmentation and identification of meiotic crossovers. The performance of the segmentation and recombination identification algorithm was assessed using a synthetic data set consisting of three generations derived from HapMap genotype data. We determined the number of crossovers called by the algorithm compared to the number of actual recombinations in each individual. Plot shows representative results of one synthetic dataset (similar results were obtained with a second, independent synthetic data set). Data are shown for two brothers (B1, B2) and two sisters (S1, S2). Combining data from the four siblings, the mean ± standard deviation for specificity was 89.0% ± 0.6% and for sensitivity was 93.3% ± 0.3%.