Figure 2
From: OPA1-related dominant optic atrophy is not strongly influenced by mitochondrial DNA background
Influence of mtDNA background on the differentoptic atrophy forms. The influence of the mtDNA background (i.e., Haplogroup J) may vary according to deleterious effect of a mutation on mitochondrial oxidative phosphorylation. For example, "mild" mutations (i.e., T14484C and G11778A) could have to be amplified by the additional negative effect of mtDNA background (i.e., G15257A, T14798C) to influence the disease expression; where as "severe mutation" (i.e., G3460A, OPA1) does not necessarily need. The dashed spears describe unclear or unproved relations.