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Table 2 Association of INSIG2 rs7566605 CC genotype and obesity (BMI ≥ 30) stratified by cohort and race

From: The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts

  Obesity
OR*
(95%
CI)
p*1 p2 BMI
(± SD)
GG/CG
BMI
(± SD)
CC
p*3 p4 Age
Obese
(± SD)
yrs
Age
Non-
Obese
(± SD)
yrs
Males
Obese
(%)
Males
Non-
Obese
(%)
ARIC
Afr.-Am.
1.02 0.78–1.34 0.89   29.60
(6.15)
29.94
(5.90)
0.25   53.38
(5.75)
53.58
(5.90)
26 45.9
CARDIA
Afr.-Am.
1.01 0.64–1.62 0.95   25.41
(5.89)
25.80
(5.65)
052   25.51
(3.72)
24.20
(3.81)
25.2 44.8
GENOA
Afr.-Am.
0.79 0.53–1.20 0.27   30.88
(6.62)
31.28
(6.69)
0.13   57.04
(10.23)
58.26
(10.43)
19.7 42.1
ARIC
White
0.95 0.82–1.10 0.50   27.03
(4.87)
26.86
(4.86)
0.25   54.42
(5.65)
54.36
(5.74)
46.1 47.6
CARDIA
White
1.07 0.64–1.79 0.80   23.73
(4.02)
23.84
(4.73)
0.70   25.94
(3.34)
25.53
(3.37)
40.1 47.6
GENOA
White
0.92 0.63–1.32 0.64   30.40
(6.35)
29.72
(5.27)
0.24   54.74
(10.70)
55.63
(11.13)
44.5 46.6
Ottawa
Cohort 1
White
0.79 0.50–1.24 0.30   NA NA -   46.27
(10.23)
45.57
(12.97)
37.1 36.4
Ottawa
Cohort 2
White
1.17 0.72–1.92 0.53   NA NA -   48.37
(10.46)
45.92
(16.29)
19.1 41.4
GENOA
Hispanic
0.94 0.64–1.38 0.74   30.90
(6.21)
29.92
(4.97)
0.03   52.77
(11.79)
56.99
(11.79)
34.2 47.6
Combined
Studies
0.96 0.86–1.06   0.38 27.85
(5.87)
27.30
(5.43)
  0.15     
  1. Afr.-Am., African-American; OR, odds ratio; CI, confidence interval; BMI, body mass index; SD, standard deviation; *adjusted for age and sex; yrs, years; NA, not applicable; p1, p-value for multivariable logistic regression, referent group is comprised of individuals in study population with combined GG and CG genotypes (recessive model); p2, p-value for analysis of combined study population; p3, p-value for analysis of mean differences among INSIG2 rs7566605 genotypes using a general linear model; p4, p-value for analysis of mean differences in BMI among rs7566605 genotypes using a general linear model and adjusting for age, gender, race, and study in the combined study population