Table 4 Distribution of SNPs haplotypes in the patients carrying only one heterozygous mutation and in patients with two characterized mutated alleles.
Haplotype | Patients with 1 mutation (n = 48) | Other patients (n = 74) | P value | ||
|---|---|---|---|---|---|
Haplotype A: T-C-G-G-C-C-T-A | 54 (0.57) | 73 (0.79) | 99 (0.67) | 137 (0.93) | 1.9 10-1 |
Haplotype B: T-T-G-G-C-C-T-A | 12 (0.13) | 23 (0.16) | 6.2 10-1 | ||
Haplotype C: T-C-G-G-T-C-T-A | 7 (0.07) | 5 (0.03) | 1.4 10-1 | ||
Haplotype D: T-C-T-A-T-C-T-A | 1 (0.01) | 0 | |||
Haplotype F: T-C-T-A-T-C-T-A | 0 | 2 (0.02) | |||
Haplotype G: T-C-G-G-C-G-T-G | 0 | 2 (0.01) | |||
Haplotype H: C-C-T-A-T-G-T-G | 0 | 1 (0.01) | |||
Haplotype I: C-T-G-G-C-G-C-G | 0 | 1 (0.01) | |||
Haplotype J: C-T-G-G-T-C-T-A | 1 | 1 (0.01) | |||
Haplotype K: C-C-T-A-C-G-C-G | 0 | 2 (0.02) | |||
Haplotype L: T-T-G-G-T-C-T-A | 0 | 2 (0.02) | |||
Haplotype E: C-C-T-A-T-G-C-G | 19 (0.20) | 19 (0.21) | 10 (0.07) | 10 (0.07) | 1.4 10-3 |
Total | 94 | 94 | 148 | 148 |