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Table 2 Odds ratios and heterogeneity results for the genetic contrasts of ACE I/D gene polymorphism for restenosis a) after PTCA-balloon, b) after PTCA-STENT, and c) after PTCA and treatment with ACE inhibitors.

From: ACE (I/D) polymorphism and response to treatment in coronary artery disease: a comprehensive database and meta-analysis involving study quality evaluation

a)       
Genetic contrast Population Studies Fixed effects
OR(95%ci)
Random effects
OR(95%ci)
I2
(%)
p-value
Q-test
D vs.I All 11 1.23(1.09–1.38) 1.34(1.09–1.65) 61 < 0.01
  Caucasians 7 1.16(1.02–1.31) 1.16(1.02–1.31) 0 0.58
  East Asians 4 1.75(1.29–2.37) 1.85(0.90–3.83) 81 < 0.01
  High quality 6 1.13(0.99–1.28) 1.13(0.99–1.28) 0 0.46
  Low quality 5 1.99(1.48–2.69) 1.95(1.21–3.14) 59 0.05
DD vs. (DI+II) All 11 1.30(1.09–1.54) 1.42(1.07–1.91) 52 0.02
  Caucasians 7 1.20(1.00–1.45) 1.20(1.00–1.45) 0 0.57
  East Asians 4 2.29(1.38–3.80) 1.88(0.65–5.45) 70 0.02
  High quality 6 1.17(0.96–1.41) 1.19(0.96–1.47) 14 0.32
  Low quality 5 2.24(1.45–3.46) 2.15(1.12–4.10) 50 0.09
(DD+ID) vs. II All 11 1.32(1.08–1.61) 1.36(1.05–1.76) 27 0.19
  Caucasians 7 1.23(0.98–1.54) 1.23(0.96–1.57) 10 0.35
  East Asians 4 1.78(1.12–2.82) 1.87(0.98–3.58) 44 0.15
  High quality 6 1.18(0.95–1.48) 1.18(0.92–1.51) 16 0.31
  Low quality 5 2.27(1.38–3.72) 2.21(1.33–3.66) 0 0.62
DD vs.II All 11 1.30(1.09–1.54) 1.42(1.07–1.91) 52 0.02
  Caucasians 7 1.20(1.00–1.45) 1.20(1.00–1.45) 0 0.57
  East Asians 4 2.29(1.38–3.80) 1.88(0.65–5.45) 70 0.02
  High quality 6 1.17(0.96–1.41) 1.19(0.96–1.47) 14 0.32
  Low quality 5 2.24(1.45–3.46) 2.15(1.12–4.10) 50 0.09
ID vs. (DD+II) All 11 0.96(0.82–1.13) 0.95(0.79–1.15) 14 0.01
  Caucasians 7 0.97(0.81–1.15) 0.95(0.77–1.18) 21 0.27
  East Asians 4 0.94(0.61–1.45) 0.93(0.55–1.55) 26 0.26
  High quality 6 0.98(0.82–1.17) 0.97(0.78–1.21) 29 0.22
  Low quality 5 0.87(0.57–1.32) 0.87(0.56–1.36) 7 0.37
b)       
Genetic contrast Population Studies Fixed effects
OR(95%ci)
Random effects
OR(95%ci)
I2
(%)
p-value
Q-test
D vs. I All 11 1.03(0.94–1.12) 1.04(0.92–1.16) 25 0.21
  Caucasians 7 1.01(0.92–1.11) 1.01(0.92–1.11) 0 0.45
  East Asians 2 0.87(0.61–1.26) 0.88(0.61–1.26) na 0.61
  High quality 6 1.02(0.93–1.12) 1.02(0.93–1.12) 1 0.41
  Low quality 5 1.05(0.84–1.31) 1.07(0.77–1.49) 52 0.08
DD vs. (DI+II) All 11 1.05(0.92–1.21) 1.07(0.92–1.24) 7 0.38
  Caucasians 7 1.03(0.89–1.20) 1.05(0.88–1.26) 20 0.28
  East Asians 2 1.18(0.61–2.27) 1.18(0.61–2.28) na 0.68
  High quality 6 1.04(0.89–1.21) 1.07(0.87–1.32) 32 0.20
  Low quality 5 1.16(0.82–1.65) 1.17(0.82–1.66) 0 0.56
(DD+ID) vs. II All 12 1.01(0.87–1.16) 0.96(0.79–1.18) 30 0.16
  Caucasians 7 1.00(0.86–1.17) 1.00(0.86–1.16) 0 0.45
  East Asians 3 0.67(0.42–1.06) 0.67(0.42–1.07) 0 0.88
  High quality 6 1.02(0.88–1.19) 1.02(0.87–1.19) 0 0.43
  Low quality 6 0.93(0.67–1.30) 0.99(0.58–1.68) 51 0.07
c)       
Genetic contrast Population Studies Fixed effects
OR(95%ci)
Random effects
OR(95%ci)
I2
(%)
p-value
Q-test
D vs. I Whites 3 1.10(0.81–1.48) 1.10(0.81–1.48) 0 0.42
DD vs. (DI+II) Whites 3 1.50(0.97–2.28) 1.74(0.78–3.87) 42.8 0.17
(DD+ID) vs. II All 5 0.85(0.52–1.38) 0.86(0.43–1.74) 31.2 0.21
  Whites 3 0.71(0.41–1.22) 0.70(0.41–1.22) 0 0.93
  East Asians 2 1.64(0.57–4.74) 1.22(0.09–16.61) na 0.05