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Table 5 Results (as P values) from the validation study genotyping and association analyses for the African American sample.*

From: Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: The HyperGEN Study

   GWAS Cases and Controls (101 pairs) African Americans (N = 1467)   
SNP Chr P Log(LVMI) LVH MAF Nearest
object
Distance (Mb)
rs409045 5p13.3 8.47E-07 0.096 0.16 0.33 RAI14 0.028
rs6450415 5q11.2 6.43E-05 0.44 0.93 0.41 FLJ35954 0.10
rs1833534 5q34 9.62E-05 0.67 0.052 0.14 CCNG1 0.044
rs6961069 7q21 7.34E-05 0.36 0.55 0.47 SEMA3C 0.040
rs10499859 7q21 3.27E-06 0.65 0.69 0.30 CD36 0.15
rs4129000 12q14.3 2.26E-05 0.83 0.51 0.21 LOC729298 0.095
rs4129218 12q13.3 5.19E-05 0.26 0.17 0.41 LOC729298 0.10
rs1155635 13q21.33 9.09E-05 0.53 0.73 0.22 KLHL1 0.27
rs238688 20p13 8.33E-05 0.013 0.09 0.28 ATRN Intron
rs756529 20q13.13 9.10E-05 0.048 0.04 0.44 KCNB1 Intron
rs10483186 22q12 3.12E-05 0.28 0.63 0.27 LOC91464 0.12
  1. *Analysis adjusted for age, sex, weight, systolic blood pressure, and diabetes; Chr = chromosome; GWAS = genome-wide association study; LVMI = left ventricular mass index defined as LV mass/height2.7; LVH = left ventricular hypertrophy defined as LVMI > 47 g/m2.7 in women and > 50 g/m2.7 in men; MAF = Overall frequency of carriers of minor allele (homozygotes + heterozygotes); SNP = single-nucleotide polymorphism