Skip to main content

Table 5 Results (as P values) from the validation study genotyping and association analyses for the African American sample.*

From: Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: The HyperGEN Study

  

GWAS Cases and Controls (101 pairs)

African Americans (N = 1467)

  

SNP

Chr

P

Log(LVMI)

LVH

MAF

Nearest

object

Distance (Mb)

rs409045

5p13.3

8.47E-07

0.096

0.16

0.33

RAI14

0.028

rs6450415

5q11.2

6.43E-05

0.44

0.93

0.41

FLJ35954

0.10

rs1833534

5q34

9.62E-05

0.67

0.052

0.14

CCNG1

0.044

rs6961069

7q21

7.34E-05

0.36

0.55

0.47

SEMA3C

0.040

rs10499859

7q21

3.27E-06

0.65

0.69

0.30

CD36

0.15

rs4129000

12q14.3

2.26E-05

0.83

0.51

0.21

LOC729298

0.095

rs4129218

12q13.3

5.19E-05

0.26

0.17

0.41

LOC729298

0.10

rs1155635

13q21.33

9.09E-05

0.53

0.73

0.22

KLHL1

0.27

rs238688

20p13

8.33E-05

0.013

0.09

0.28

ATRN

Intron

rs756529

20q13.13

9.10E-05

0.048

0.04

0.44

KCNB1

Intron

rs10483186

22q12

3.12E-05

0.28

0.63

0.27

LOC91464

0.12

  1. *Analysis adjusted for age, sex, weight, systolic blood pressure, and diabetes; Chr = chromosome; GWAS = genome-wide association study; LVMI = left ventricular mass index defined as LV mass/height2.7; LVH = left ventricular hypertrophy defined as LVMI > 47 g/m2.7 in women and > 50 g/m2.7 in men; MAF = Overall frequency of carriers of minor allele (homozygotes + heterozygotes); SNP = single-nucleotide polymorphism