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Table 1 Analysis of association between LXR alleles and T2D in French cases vs control

From: Functional and genetic analysis in type 2 diabetes of Liver X receptor alleles – a cohort study

SNP          Call HWE  
Name Position Allelea   #11b #12 #22 %1c %2 rate % P valued O.R. ± C.I.e
LXRA            
rs4752822 5' T>C NDg 522 332 53 76 24 96 0.93 1.04 [0.89–1.21]
    T2Dg 537 360 57 75 25    
rs61896015 intron 2 C>A ND 711 180 16 88 12 97 0.79 1.13 [0.93–1.37]
    T2D 729 221 15 87 13    
rs12221497 intron 2 G>A ND 718 180 17 88 12 97 0.69 1.09 [0.90–1.33]
    T2D 727 216 13 87 13    
rs2279239 intron 4 T>C ND 518 328 52 76 24 97 0.94 1.03 [0.89–1.20]
    T2D 549 355 60 75 25    
rs2279238 exon 5 C>T ND 715 195 12 88 12 98 0.62 0.99 [0.81–1.2]
    T2D 754 192 17 88 12    
LXRB            
rs35463555 promoter G>A ND 417 388 106 67 33 96 0.74 0.94 [0.82–1.08]
  (-2046)   T2D 433 432 84 68 32    
rs17373080 promoter C>G ND 411 386 104 67 33 96 0.42 0.94 [0.82–1.08]
  (-202)   T2D 430 438 80 68 32    
rs2248949 intron 6 C>T ND 310 432 139 60 40 93 0.05 1.02 [0.90–1.17]
    T2D 303 476 136 59 41    
  1. a) Common allele is written first. b) #11 = number of subjects homozygous for common allele, #12 = number of heterozygous subjects, #22 = number of subjects homozygous for rare allele. c) Major allele frequency. d) HWE P values were calculated in HAPLOVIEW [32]. e) O.R. ± C.I. = odds ratio ± confidence intervals. ORs were calculated as (number allele 2 among cases * number allele 1 among controls)/(number allele 1 among cases * number allele 2 among controls). f) Pearson's Chi2 (d.f. = 1) was used to compare allele frequencies between T2D-cases and controls. g) ND = non-diabetic controls, T2D = type 2 diabete