Figure 4From: Prevalence of pathogenetic MC4R mutations in Italian children with early Onset obesity, tall stature and familial history of obesity Binding Data. Competitive displacement binding affinity studies of the polymorphic hMC4Rs examined in this study. I125NDP-MSH was used to competitively displace non-labeled NDP-MSH in a dose-response fashion. The endogenous agonists were unable to stimulate the Q307X MC4R at up to 1 μM concentrations.Back to article page