PRNP variation in UK sporadic and variant Creutzfeldt Jakob disease highlights genetic risk factors and a novel non-synonymous polymorphism

Table 3 Statistical analysis of PRNP polymorphism frequencies

	Chi-Squared Test - P value
Comparison	Codon 129	Codon 117	24 bp Deletion
Sequenced sCJD (n = 309) vs. All NCJDSU sCJD cases (n = 647)	0.582	NA	NA
UK DNA Controls (n = 192) vs. Scottish Blood Donors (n = 778)	0.185	0.584	0.452*
Sequenced sCJD (n = 309) vs. UK DNA Controls (n = 192)	<0.001	0.975	0.700*
Sequenced sCJD (n = 309) vs. Scottish Blood Donors (n = 778)	<0.001	0.295	0.978*
Sequenced vCJD (n = 118) vs. Scottish Blood Donors (n = 778)	<0.001	NA	0.861*

*: Chi-Squared approximation may be incorrect due to low numbers; NA: no comparison could be made

ISSN: 1471-2350