Power of multifactor dimensionality reduction and penalized logistic regression for detecting gene-gene Interaction in a case-control study

Table 5 Results from single SNP association analyses: Top 20 SNPs showing significant association with acute rejection according to Fisher's exact test. The p values are not corrected for multiple testing.

SNPs	genes	pvalue	(Putative) Function
rs2147668	RFC3	0.0001	Replication factor C 3
rs875740	ABCC1	0.0006	plasma membrane drug-efflux pump
rs2238136	VDR	0.0009	Vitamin D receptor
rs4988515	IGFBP1	0.0009	Insulin-like growth factor binding protein 1
rs442332	TNFRSF17	0.0009	B-cell maturation factor
rs2211463	Admixture	0.0010	Unknown
rs2189394	Admixture	0.0012	Unknown
rs2741045	UGT1A9	0.0013	Drug metabolizing enzyme
rs288326	FRZB	0.0013	frizzled-related protein
rs1049897	MGP	0.0014	Regulator of cartilage development
rs10276036	ABCB1	0.0015	Initiate T lymphocyte-mediated immunity
rs1800875	CMA1	0.0019	Degradation of the extracelluar matrix
rs4072037	MUC1	0.0021	encodes a mucin glycoprotein(s)
rs11539762	MYEOV	0.0023	myeloma overexpressed gene
rs2241339	ABCB11	0.0024	Progressive intrahepatic cholestasis-2
rs2741046	UGT1A9	0.0028	Drug metabolizing enzyme
rs2014800	ABCC1	0.0030	plasma membrane drug-efflux pump
rs2695232	SOD3	0.0031	superoxide dismutase 3
rs1052369	ANKRD29	0.0033	ankyrin repeat domain 29
rs2305030	LTK	0.0033	leukocyte receptor tyrosine kinase

ISSN: 1471-2350