A maternal GOT1 novel variant associated with early-onset severe preeclampsia identified by whole-exome sequencing

Table 1 Clinical features of the patients with early-onset severe preeclampsia

Variables	P1	P2	P3	P4	P5
Age (years)	35	27	29	31	31
Pro-gestational BMI (kg/m²)	22.9	22.1	20	26.8	22
Prior pre-eclampsia	+			+
Registered gestational age (weeks)	28	27	27	26	31
First birth		+	+	+	+
Anemia
Thrombocytopenia			+	+
Impaired liver function			+	+	+
Progressive renal insufficiency	+	+	+	+
Serous membrane fluid		+			+
Pulmonary edema			+		+
Hypoproteinemia	+		+		–
HELLP syndrome			+	+	+
Intrahepatic cholestasis of pregnancy					+
Placental abruption
Late abortion		+	+	+
Premature birth					+
Cesarean delivery		+	+		+
Fetal growth restriction	+
Stillbirth	+			+
Low birth weight infant		+	+		+

ISSN: 1471-2350