Fig. 2

The molecular model of GOT1 protein. a Close view of wild type GOT1 protein structure (PDB ID: 3II0, Ugochukwu, E., Pilka, E., Cooper, C., Bray, J.E., Yue, W.W., Muniz, J., Chaikuad, A., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Kavanagh, K.L., Oppermann, U., Structural Genomics Consortium (SGC). Crystal structure of human Glutamate oxaloacetate transaminase 1 (GOT1)). The whole protein is shown as cartoon in rainbow and 15th proline side chain is shown as sticks. b Close view of P15R mutant type GOT1 protein structure. The whole protein is shown as cartoon in rainbow and 15th arginine side chain is shown as sticks. c Electrostatic surface view of the wild type GOT1 protein. Electrostatic potential is expressed as a spectrum ranging from − 64 kT/e (red) to + 64 kT/e (blue). Black arrow indicates the 15th residue proline. d Electrostatic surface view of the P15R variant in GOT1 protein. Electrostatic potential is expressed as a spectrum ranging from − 64 kT/e (red) to + 64 kT/e (blue). Black arrow indicates the 15th residue arginine