ABCG2 rs2231142 variant in hyperuricemia is modified by SLC2A9 and SLC22A12 polymorphisms and cardiovascular risk factors in an elderly community-dwelling population

Table 5 Association between ABCG2 rs2231142 variants and HUA according to cardiovascular risk exposure

Cardiovascular risk	Total		Male		Female
Cardiovascular risk	OR^a 95%CI	p^b	OR^a 95%CI	p^b	OR^a 95%CI	p^b
Obesity status
BMI < 24 kg/m²	1.56 (1.07–2.31)	0.022	1.43 (0.84–2.45)	0.191	1.51 (0.92–2.49)	0.161
BMI ≥ 24 kg/m²	1.66 (1.18–2.36)	0.004	1.86 (1.15–3.03)	0.012	1.59 (1.04–3.04)	0.045
Hypertension
No	1.43 (1.05–2.04)	0.047	1.68 (1.02–2.78)	0.043	1.40 (0.81–2.37)	0.219
Yes	1.88 (1.30–2.71)	0.001	1.91 (1.13–3.24)	0.015	1.83 (1.09–3.08)	0.021
Hyper TG
TG < 1.7 mmol/L	1.53 (1.14–2.07)	0.005	1.58 (1.04–2.83)	0.031	1.51 (0.98–2.33)	0.060
TG ≥ 1.7 mmol/L	2.52 (1.33–4.60)	0.003	2.41 (1.06–4.53)	0.035	2.57 (1.10–6.01)	0.030
Hyper LDL
LDL < 3.4 mmol/L	1.43 (1.01–2.02)	0.043	1.68 (1.08–2.62)	0.021	1.18 (0.66–2.09)	0.582
LDL ≥ 3.4 mmol/L	1.90 (1.39–2.79)	0.001	1.75 (1.12–4.80)	0.024	1.98 (1.20–3.34)	0.008
Low HDL
HDL ≥1.0 mmol/L	1.57 (1.18–2.09)	0.002	1.58 (1.06–2.34)	0.024	1.61 (0.93–2.43)	0.087
HDL < 1.0 mmol/L	2.21 (1.21–4.01)	0.010	2.50 (1.12–5.67)	0.026	1.92 (0.78–4.74)	0.156

^a increased odds of HUA associated with each copy of the T allele in ABCG2 rs2231142
^bp value for the logistic regression adjusted by age, gender, serum cretinine, BMI, hypertension, TG, LDL, and HDL

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