ABCG2 rs2231142 variant in hyperuricemia is modified by SLC2A9 and SLC22A12 polymorphisms and cardiovascular risk factors in an elderly community-dwelling population

Table 4 Association between genotypes of three SNPs and serum urate levels in the study population, separated by gender

Gene (SNP)	Code /other allele (1/2)	SUA (mean ± SD) μmol/L			p^a	p^b	p^b	p^b
		1/1	1/2	2/2		1/1 vs 1/2	1/2 vs 2/2	1/1 vs 2/2
SLC2A9 rs3733951	C/T
Total		327.24 ± 82.39	311.09 ± 77.71	302.96 ± 76.89	0.005	0.262	0.104	0.005
Male		337.71 ± 72.96	326.42 ± 78.23	324.04 ± 78.28	0.356	–	–	–
Female		308.57 ± 94.96	290.43 ± 72.17	274.96 ± 69.89	0.006	0.073	0.379	0.015
ABCG2 rs2231142	T/G
Total		337.46 ± 71.25	317.51 ± 80.53	287.46 ± 75.13	6.98 × 10⁻⁸	0.052	5.42 × 10⁻⁵	4.40 × 10⁻⁶
Male		348.20 ± 68.85	337.90 ± 78.10	313.32 ± 73.83	1.85 × 10⁻⁵	1.26 × 10⁻⁴	1.000	0.003
Female		323.32 ± 72.67	288.21 ± 74.89	276.18 ± 71.65	3.45 × 10⁻⁴	0.012	0.236	2.67 × 10⁻⁴
SLC22A12 rs893006	G/T
Total		315.33 ± 80.50	302.80 ± 75.98	297.60 ± 66.03	0.012	0.023	1.000	0.186
Male		392.11 ± 79.52	320.66 ± 72.85	313.54 ± 63.71	0.087	–	–	–
Female		289.41 ± 75.08	281.58 ± 74.28	276.17 ± 64.37	0.402	–	–	–

^aANOVA comparison between groups;
^bBonferroni test; 1 = code allele; 2 = other allele; SNP single-nucleotide polymorphism, SUA serum uric acid

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