ABCG2 rs2231142 variant in hyperuricemia is modified by SLC2A9 and SLC22A12 polymorphisms and cardiovascular risk factors in an elderly community-dwelling population

Table 3 Association of risk alleles of uric acid genes with sUA levels and HUA

Gene	SNP	Coded/other allele	CAF (%)	sUA level		Hyperuricemia
Gene	SNP	Coded/other allele	CAF (%)	Beta (SE)	p^a	OR (95%CI)	p^b
Total
SLC2A9	rs3733591	C/T	33.58	0.08 (3.02)	0.002	1.34 (1.03–1.74)	0.029
ABCG2	rs2231142	T/G	29.48	0.16 (3.98)	6.75 × 10⁻⁹	1.63 (1.27–2.11)	1.65 × 10^− 4
SLC22A12	rs893006	G/T	74.00	0.07 (3.25)	0.006	1.33 (0.99–1.78)	0.061
Male
SLC2A9	rs3733591	C/T	32.35	0.05 (3.96)	0.122	1.09 (0.72–1.64)	0.699
ABCG2	rs2231142	T/G	29.69	0.16 (4.15)	4.48 × 10⁻⁷	1.70 (1.20–2.42)	0.003
SLC22A12	rs893006	G/T	75.32	0.08 (4.34)	0.018	1.49 (0.98–2.28)	0.064
Female
SLC2A9	rs3733591	C/T	34.48	0.13 (4.68)	0.002	1.89 (1.26–2.85)	0.002
ABCG2	rs2231142	T/G	29.19	0.17 (4.68)	6.56 × 10⁻⁵	1.60 (1.10–2.32)	0.013
SLC22A12	rs893006	G/T	72.19	0.06 (4.90)	0.140	1.17 (0.75–1.84)	0.489

CAF code allele frequency
^aLiner regression adjusted by age, gender, BMI, hypertension, serum creatinine, TG, HDL, and LDL
^bLogistic regression adjusted by age, gender, BMI, hypertension, serum creatinine, TG, HDL, and LDL

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