Serum miR-101-3p combined with pepsinogen contributes to the early diagnosis of gastric cancer

BMC Medical Genetics

Table 4 The diagnostic value of serum marker combinations on atrophic gastritis (AG) and gastric cancer (GC)

		Sensitivity	Specificity	AUC	95% CI	P value
C vs. AG	PG I + PG I/II	67.21%	84.00%	0.807	0.727–0.888	< 0.0001
	miR-101-3p + PG I	88.52%	64.04%	0.890	0.828–0.952	< 0.0001
	miR-101-3p + PG I/II	88.52%	84.00%	0.892	0.827–0.957	< 0.0001
	miR-101-3p + PG I + PG I/II	95.08%	80.00%	0.917	0.863–0.972	< 0.0001
C vs. GC	PG I + PG I/II	91.86%	64.86%	0.842	0.787–0.897	< 0.0001
	miR-101-3p + PG I	83.72%	83.78%	0.918	0.882–0.954	< 0.0001
	miR-101-3p + PG I/II	95.35%	88.52%	0.891	0.849–0.933	< 0.0001
	miR-101-3p + PG I + PG I/II	77.91%	91.89%	0.928	0.895–0.961	< 0.0001
AG vs. GC	PG I + PG I/II	54.65%	88.52%	0.768	0.691–0.844	< 0.0001
	miR-101-3p + PG I	54.65%	95.08%	0.833	0.770–0.897	< 0.0001
	miR-101-3p + PG I/II	60.47%	86.89%	0.798	0.728–0.868	< 0.0001
	miR-101-3p + PGI + PG I/II	80.23%	77.05%	0.856	0.795–0.916	< 0.0001

Notes: AUC Area-under-the-curve, CI confidence intervals, PG Pepsinogen, AG Atrophic gastritis, GC Gastric cancer, C Normal control. The diagnostic value of variables was analyzed by receiver operating characteristics (ROC) analysis. Youden index was used to determine the optimal cutoff value (Cut off). A P < 0.05 was considered as statistically significant

ISSN: 1471-2350