Serum miR-101-3p combined with pepsinogen contributes to the early diagnosis of gastric cancer

BMC Medical Genetics

Table 3 The diagnostic value of serum marker alone on atrophic gastritis (AG) and gastric cancer (GC)

	Cut off	Sensitivity	Specificity	AUC	95% CI	P-value
C vs. AG	miR-101-3p < 0.8765	80.33%	80.00%	0.8493	0.771–0.928	< 0.0001
	PG I < 71.56 (μg/l)	77.05%	66.00%	0.7187	0.621–0.816	< 0.0001
	PG I/II ratio < 5.6	60.66%	82.00%	0.7549	0.666–0.844	< 0.0001
	CEA > 2.52 (ng/ml)	41.62%	86.00%	0.6289	0.526–0.732	0.0198
C vs. GC	miR-101-3p < 0.759	72.09%	86.49%	0.8749	0.829–0.921	< 0.0001
	PG I < 59.98 (μg/l)	59.3%	83.78%	0.7702	0.704–0.836	< 0.0001
	PG I/II ratio < 4.22	56.98%	87.39%	0.7697	0.704–0.835	< 0.0001
	CEA > 2.875 (ng/ml)	75.58%	81.98%	0.8235	0.760–0.887	< 0.0001
AG vs. GC	miR-101-3p < 0.756	68.60%	77.05%	0.7710	0.697–0.845	< 0.0001
	PG I < 58.22 (μg/l)	51.16%	86.89%	0.7130	0.631–0.795	< 0.0001
	PG I/II ratio < 4.01	52.33%	83.61%	0.6760	0.587–0.764	< 0.0001
	CEA > 2.875 (ng/ml)	75.58%	75.41%	0.7850	0.710–0.860	< 0.0001

Notes: AUC Area-under-the-curve, CI Confidence intervals, PG Pepsinogen, AG Atrophic gastritis, GC Gastric cancer, C Normal control. The diagnostic value of variables was analyzed by receiver operating characteristics (ROC) analysis. Youden index was used to determine the optimal cutoff value (Cut off). A P < 0.05 was considered as statistically significant

ISSN: 1471-2350